Antidepressants for pain management in adults with chronic pain: a network meta-analysis

Hollie Birkinshaw, Claire Friedrich, Peter Cole, Christopher Eccleston, Marc Serfaty, Gavin Stewart, Simon White, R. Andrew Moore, Tamar Pincus

Research output: Contribution to journalArticlepeer-review


Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the comparative efficacy and safety of antidepressants for adults with chronic pain. We will achieve this by:. assessing the efficacy of antidepressants by type, class and dose in improving pain, mood, patient global impression of change, physical functioning, sleep quality and quality of life; assessing the number of adverse events of antidepressants by type, class and dose; ranking antidepressants in the efficacy of treating pain, mood and adverse events.

Original languageEnglish
Article numberCD014682
JournalCochrane Database of Systematic Reviews
Issue number4
Publication statusPublished - 7 Apr 2021

ASJC Scopus subject areas

  • Pharmacology (medical)

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