Anticardiolipin antibodies, livedo reticularis, and major cerebrovascular and renal disease in systemic lupus erythematosus

N J McHugh, J Maymo, R P Skinner, I James, P J Maddison

Research output: Contribution to journalArticle

Abstract

Increased levels of IgG anticardiolipin antibodies (ACA) were found in 23 of 98 patients (23%) with systemic lupus erythematosus. Increased levels of IgM ACA were found less frequently (5%). All four patients with major cerebrovascular events had increased IgG ACA, including the two with highest levels, both of whom were men. Six of nine patients with livedo reticularis had increased IgG ACA. In turn, this clinical feature was associated with cerebrovascular disease in two and renal disease in another six. IgG ACA were not associated with other thromboembolic events, thrombocytopenia, serum IgG, or autoantibodies to Ro(SSA), La(SSB), U1RNP, Sm, or double or single stranded DNA.
Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume47
Issue number2
Publication statusPublished - Feb 1988

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Livedo Reticularis
Cerebrovascular Disorders
Anticardiolipin Antibodies
Systemic Lupus Erythematosus
Immunoglobulin G
Kidney
Single-Stranded DNA
Thrombocytopenia
Autoantibodies
Immunoglobulin M
DNA
Serum

Keywords

  • Adult
  • Autoantibodies
  • Cardiolipins
  • Cerebrovascular Disorders
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G
  • Immunoglobulin M
  • Kidney Diseases
  • Lupus Erythematosus, Systemic
  • Male
  • Skin
  • Vascular Diseases

Cite this

Anticardiolipin antibodies, livedo reticularis, and major cerebrovascular and renal disease in systemic lupus erythematosus. / McHugh, N J; Maymo, J; Skinner, R P; James, I; Maddison, P J.

In: Annals of the Rheumatic Diseases, Vol. 47, No. 2, 02.1988, p. 110-115.

Research output: Contribution to journalArticle

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