Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography

L. W. Lawrence Woo; Delphine S. Fischer; Christopher M. Sharland; Melanie Trusselle; Paul A. Foster; Surinder K. Chander; Anna Di Fiore; Claudiu T. Supuran; Giuseppina De Simone; Atul Purohit; Michael J. Reed; Barry V. L. Potter

doi:10.1158/1535-7163.MCT-08-0195

Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography

L. W. Lawrence Woo, Delphine S. Fischer, Christopher M. Sharland, Melanie Trusselle, Paul A. Foster, Surinder K. Chander, Anna Di Fiore, Claudiu T. Supuran, Giuseppina De Simone, Atul Purohit, Michael J. Reed, Barry V. L. Potter

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

40 Citations (SciVal)

Original language	English
Pages (from-to)	2435-2444
Journal	Molecular Cancer Therapeutics
Volume	7
Issue number	8
DOIs	https://doi.org/10.1158/1535-7163.MCT-08-0195
Publication status	Published - 2008

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10.1158/1535-7163.MCT-08-0195

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Woo, L. W. L., Fischer, D. S., Sharland, C. M., Trusselle, M., Foster, P. A., Chander, S. K., Di Fiore, A., Supuran, C. T., De Simone, G., Purohit, A., Reed, M. J., & Potter, B. V. L. (2008). Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography. Molecular Cancer Therapeutics, 7(8), 2435-2444. https://doi.org/10.1158/1535-7163.MCT-08-0195

Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography. / Woo, L. W. Lawrence; Fischer, Delphine S.; Sharland, Christopher M. et al.
In: Molecular Cancer Therapeutics, Vol. 7, No. 8, 2008, p. 2435-2444.

Research output: Contribution to journal › Article › peer-review

Woo, LWL, Fischer, DS, Sharland, CM, Trusselle, M, Foster, PA, Chander, SK, Di Fiore, A, Supuran, CT, De Simone, G, Purohit, A, Reed, MJ & Potter, BVL 2008, 'Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography', Molecular Cancer Therapeutics, vol. 7, no. 8, pp. 2435-2444. https://doi.org/10.1158/1535-7163.MCT-08-0195

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title = "Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography",

author = "Woo, \{L. W. Lawrence\} and Fischer, \{Delphine S.\} and Sharland, \{Christopher M.\} and Melanie Trusselle and Foster, \{Paul A.\} and Chander, \{Surinder K.\} and \{Di Fiore\}, Anna and Supuran, \{Claudiu T.\} and \{De Simone\}, Giuseppina and Atul Purohit and Reed, \{Michael J.\} and Potter, \{Barry V. L.\}",

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AU - Trusselle, Melanie

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AU - Chander, Surinder K.

AU - Di Fiore, Anna

AU - Supuran, Claudiu T.

AU - De Simone, Giuseppina

AU - Purohit, Atul

AU - Reed, Michael J.

AU - Potter, Barry V. L.

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Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography

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