'AND'-based fluorescence scaffold for the detection of ROS/RNS and a second analyte

Maria L. Odyniec, Adam C. Sedgwick, Alexander H. Swan, Maria Weber, T. M. Simon Tang, Jordan E. Gardiner, Miao Zhang, Yun Bao Jiang, Gabriele Kociok-Kohn, Robert B.P. Elmes, Steven D. Bull, Xiao Peng He, Tony D. James

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Traditionally, fluorescence probes have focused on the detection of a single biomarker for a specific process. In this work, we set out to develop a number of fluorescence probes that enable the detection of a chosen analyte in the presence of reactive oxygen/nitrogen species (ROS/RNS). These fluorescence probes when activated result in the formation of the highly fluorescent pink dye, resorufin. Therefore, we have labelled these fluorescent probes as -Pinkments'. Our first -Pinkment' was shown to detect biologically relevant concentrations of ONOO- and have an excellent selectivity against other ROS/RNS. Pinkment-OH was developed to provide a core unit which could be easily functionalised to produce a range of -AND' based fluorescence probes for the detection of ROS/RNS and a second analyte. For proof of concept, we synthesised Pinkment-OTBS and Pinkment-OAc. These -AND'-based probes were successfully shown to detect ROS/RNS and F- or esterase, respectively.

Original languageEnglish
Pages (from-to)8466-8469
Number of pages4
JournalChemical Communications
Volume54
Early online date27 Jun 2018
DOIs
Publication statusE-pub ahead of print - 27 Jun 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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