Analysis of spatial mobility in subjects from a dengue endemic urban locality in Morelos State, Mexico

Jorge Abelardo Falcón-Lezama, René Santos-Luna, Susana Román-Pérez, Ruth Aralí Martínez-Vega, Marco Arieli Herrera-Valdez, Ángel Fernando Kuri-Morales, Ben Adams, Pablo Antonio Kuri-Morales, Malaquías López-Cervantes, José Ramos-Castañeda

Research output: Contribution to journalArticle

Abstract

Introduction Mathematical models and field data suggest that human mobility is an important driver for Dengue virus transmission. Nonetheless little is known on this matter due the lack of instruments for precise mobility quantification and study design difficulties. Materials and methods We carried out a cohort-nested, case-control study with 126 individuals (42 cases, 42 intradomestic controls and 42 population controls) with the goal of describing human mobility patterns of recently Dengue virus-infected subjects, and comparing them with those of noninfected subjects living in an urban endemic locality. Mobility was quantified using a GPSdata logger registering waypoints at 60-second intervals for a minimum of 15 natural days. Results Although absolute displacement was highly biased towards the intradomestic and peridomestic areas, occasional displacements exceeding a 100-Km radius from the center of the studied locality were recorded for all three study groups and individual displacements were recorded traveling across six states from central Mexico. Additionally, cases had a larger number of visits out of the municipality?s administrative limits when compared to intradomestic controls (cases: 10.4 versus intradomestic controls: 2.9, p = 0.0282). We were able to identify extradomestic places within and out of the locality that were independently visited by apparently non-related infected subjects, consistent with houses, working and leisure places. Conclusions Results of this study show that human mobility in a small urban setting exceeded that considered by local health authority's administrative limits, and was different between recently infected and non-infected subjects living in the same household. These observations provide important insights about the role that human mobility may have in Dengue virus transmission and persistence across endemic geographic areas that need to be taken into account when planning preventive and control measures. Finally, these results are a valuable reference when setting the parameters for future mathematical modeling studies.

LanguageEnglish
Article numbere0172313
JournalPLoS ONE
Volume12
Issue number2
DOIs
StatusPublished - 22 Feb 2017

Fingerprint

Spatial Analysis
dengue
Dengue
Mexico
Dengue virus
Dengue Virus
virus transmission
Viruses
mathematical models
Population Control
Leisure Activities
case-control studies
Case-Control Studies
control methods
households
Theoretical Models
planning
experimental design
Health
Mathematical models

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Falcón-Lezama, J. A., Santos-Luna, R., Román-Pérez, S., Martínez-Vega, R. A., Herrera-Valdez, M. A., Kuri-Morales, Á. F., ... Ramos-Castañeda, J. (2017). Analysis of spatial mobility in subjects from a dengue endemic urban locality in Morelos State, Mexico. PLoS ONE, 12(2), [e0172313]. DOI: 10.1371/journal.pone.0172313

Analysis of spatial mobility in subjects from a dengue endemic urban locality in Morelos State, Mexico. / Falcón-Lezama, Jorge Abelardo ; Santos-Luna, René; Román-Pérez, Susana; Martínez-Vega, Ruth Aralí ; Herrera-Valdez, Marco Arieli ; Kuri-Morales, Ángel Fernando ; Adams, Ben; Kuri-Morales, Pablo Antonio; López-Cervantes, Malaquías; Ramos-Castañeda, José.

In: PLoS ONE, Vol. 12, No. 2, e0172313, 22.02.2017.

Research output: Contribution to journalArticle

Falcón-Lezama, JA, Santos-Luna, R, Román-Pérez, S, Martínez-Vega, RA, Herrera-Valdez, MA, Kuri-Morales, ÁF, Adams, B, Kuri-Morales, PA, López-Cervantes, M & Ramos-Castañeda, J 2017, 'Analysis of spatial mobility in subjects from a dengue endemic urban locality in Morelos State, Mexico' PLoS ONE, vol 12, no. 2, e0172313. DOI: 10.1371/journal.pone.0172313
Falcón-Lezama JA, Santos-Luna R, Román-Pérez S, Martínez-Vega RA, Herrera-Valdez MA, Kuri-Morales ÁF et al. Analysis of spatial mobility in subjects from a dengue endemic urban locality in Morelos State, Mexico. PLoS ONE. 2017 Feb 22;12(2). e0172313. Available from, DOI: 10.1371/journal.pone.0172313
Falcón-Lezama, Jorge Abelardo ; Santos-Luna, René ; Román-Pérez, Susana ; Martínez-Vega, Ruth Aralí ; Herrera-Valdez, Marco Arieli ; Kuri-Morales, Ángel Fernando ; Adams, Ben ; Kuri-Morales, Pablo Antonio ; López-Cervantes, Malaquías ; Ramos-Castañeda, José. / Analysis of spatial mobility in subjects from a dengue endemic urban locality in Morelos State, Mexico. In: PLoS ONE. 2017 ; Vol. 12, No. 2.
@article{9b0bccf9968149b58ac940d6ee074554,
title = "Analysis of spatial mobility in subjects from a dengue endemic urban locality in Morelos State, Mexico",
abstract = "Introduction Mathematical models and field data suggest that human mobility is an important driver for Dengue virus transmission. Nonetheless little is known on this matter due the lack of instruments for precise mobility quantification and study design difficulties. Materials and methods We carried out a cohort-nested, case-control study with 126 individuals (42 cases, 42 intradomestic controls and 42 population controls) with the goal of describing human mobility patterns of recently Dengue virus-infected subjects, and comparing them with those of noninfected subjects living in an urban endemic locality. Mobility was quantified using a GPSdata logger registering waypoints at 60-second intervals for a minimum of 15 natural days. Results Although absolute displacement was highly biased towards the intradomestic and peridomestic areas, occasional displacements exceeding a 100-Km radius from the center of the studied locality were recorded for all three study groups and individual displacements were recorded traveling across six states from central Mexico. Additionally, cases had a larger number of visits out of the municipality?s administrative limits when compared to intradomestic controls (cases: 10.4 versus intradomestic controls: 2.9, p = 0.0282). We were able to identify extradomestic places within and out of the locality that were independently visited by apparently non-related infected subjects, consistent with houses, working and leisure places. Conclusions Results of this study show that human mobility in a small urban setting exceeded that considered by local health authority's administrative limits, and was different between recently infected and non-infected subjects living in the same household. These observations provide important insights about the role that human mobility may have in Dengue virus transmission and persistence across endemic geographic areas that need to be taken into account when planning preventive and control measures. Finally, these results are a valuable reference when setting the parameters for future mathematical modeling studies.",
author = "Falc{\'o}n-Lezama, {Jorge Abelardo} and Ren{\'e} Santos-Luna and Susana Rom{\'a}n-P{\'e}rez and Mart{\'i}nez-Vega, {Ruth Aral{\'i}} and Herrera-Valdez, {Marco Arieli} and Kuri-Morales, {{\'A}ngel Fernando} and Ben Adams and Kuri-Morales, {Pablo Antonio} and Malaqu{\'i}as L{\'o}pez-Cervantes and Jos{\'e} Ramos-Casta{\~n}eda",
year = "2017",
month = "2",
day = "22",
doi = "10.1371/journal.pone.0172313",
language = "English",
volume = "12",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science (PLOS)",
number = "2",

}

TY - JOUR

T1 - Analysis of spatial mobility in subjects from a dengue endemic urban locality in Morelos State, Mexico

AU - Falcón-Lezama,Jorge Abelardo

AU - Santos-Luna,René

AU - Román-Pérez,Susana

AU - Martínez-Vega,Ruth Aralí

AU - Herrera-Valdez,Marco Arieli

AU - Kuri-Morales,Ángel Fernando

AU - Adams,Ben

AU - Kuri-Morales,Pablo Antonio

AU - López-Cervantes,Malaquías

AU - Ramos-Castañeda,José

PY - 2017/2/22

Y1 - 2017/2/22

N2 - Introduction Mathematical models and field data suggest that human mobility is an important driver for Dengue virus transmission. Nonetheless little is known on this matter due the lack of instruments for precise mobility quantification and study design difficulties. Materials and methods We carried out a cohort-nested, case-control study with 126 individuals (42 cases, 42 intradomestic controls and 42 population controls) with the goal of describing human mobility patterns of recently Dengue virus-infected subjects, and comparing them with those of noninfected subjects living in an urban endemic locality. Mobility was quantified using a GPSdata logger registering waypoints at 60-second intervals for a minimum of 15 natural days. Results Although absolute displacement was highly biased towards the intradomestic and peridomestic areas, occasional displacements exceeding a 100-Km radius from the center of the studied locality were recorded for all three study groups and individual displacements were recorded traveling across six states from central Mexico. Additionally, cases had a larger number of visits out of the municipality?s administrative limits when compared to intradomestic controls (cases: 10.4 versus intradomestic controls: 2.9, p = 0.0282). We were able to identify extradomestic places within and out of the locality that were independently visited by apparently non-related infected subjects, consistent with houses, working and leisure places. Conclusions Results of this study show that human mobility in a small urban setting exceeded that considered by local health authority's administrative limits, and was different between recently infected and non-infected subjects living in the same household. These observations provide important insights about the role that human mobility may have in Dengue virus transmission and persistence across endemic geographic areas that need to be taken into account when planning preventive and control measures. Finally, these results are a valuable reference when setting the parameters for future mathematical modeling studies.

AB - Introduction Mathematical models and field data suggest that human mobility is an important driver for Dengue virus transmission. Nonetheless little is known on this matter due the lack of instruments for precise mobility quantification and study design difficulties. Materials and methods We carried out a cohort-nested, case-control study with 126 individuals (42 cases, 42 intradomestic controls and 42 population controls) with the goal of describing human mobility patterns of recently Dengue virus-infected subjects, and comparing them with those of noninfected subjects living in an urban endemic locality. Mobility was quantified using a GPSdata logger registering waypoints at 60-second intervals for a minimum of 15 natural days. Results Although absolute displacement was highly biased towards the intradomestic and peridomestic areas, occasional displacements exceeding a 100-Km radius from the center of the studied locality were recorded for all three study groups and individual displacements were recorded traveling across six states from central Mexico. Additionally, cases had a larger number of visits out of the municipality?s administrative limits when compared to intradomestic controls (cases: 10.4 versus intradomestic controls: 2.9, p = 0.0282). We were able to identify extradomestic places within and out of the locality that were independently visited by apparently non-related infected subjects, consistent with houses, working and leisure places. Conclusions Results of this study show that human mobility in a small urban setting exceeded that considered by local health authority's administrative limits, and was different between recently infected and non-infected subjects living in the same household. These observations provide important insights about the role that human mobility may have in Dengue virus transmission and persistence across endemic geographic areas that need to be taken into account when planning preventive and control measures. Finally, these results are a valuable reference when setting the parameters for future mathematical modeling studies.

UR - http://www.scopus.com/inward/record.url?scp=85013793886&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1371/journal.pone.0172313

UR - http://dx.doi.org/10.1371/journal.pone.0172313

U2 - 10.1371/journal.pone.0172313

DO - 10.1371/journal.pone.0172313

M3 - Article

VL - 12

JO - PLoS ONE

T2 - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 2

M1 - e0172313

ER -