TY - JOUR
T1 - Analyses of clonality and the evolution of bacterial pathogens
AU - Feil, E J
AU - Enright, M C
N1 - ID number: ISI:000222534100016
PY - 2004
Y1 - 2004
N2 - The existence of bacterial clones was evident in early phenotypic studies that recognised high levels of similarity in geographically and temporally separated isolates. Multilocus sequence typing (MLST) has become the most common method for genetically characterizing clones of several bacterial pathogens, allowing the tracking of hypervirulent/antibiotic-resistant lineages. MLST has also been used to examine the way that bacterial populations, and in particular, bacterial clones evolve. Visualisation of MLST datasets has required the development of novel tools, such as 'eBURST', a key program in constructing evolutionary models that detail how methicillin resistant Staphylococcus aureus (MRSA) and other clones emerge and spread.
AB - The existence of bacterial clones was evident in early phenotypic studies that recognised high levels of similarity in geographically and temporally separated isolates. Multilocus sequence typing (MLST) has become the most common method for genetically characterizing clones of several bacterial pathogens, allowing the tracking of hypervirulent/antibiotic-resistant lineages. MLST has also been used to examine the way that bacterial populations, and in particular, bacterial clones evolve. Visualisation of MLST datasets has required the development of novel tools, such as 'eBURST', a key program in constructing evolutionary models that detail how methicillin resistant Staphylococcus aureus (MRSA) and other clones emerge and spread.
UR - https://www.scopus.com/pages/publications/2942555285
U2 - 10.1016/j.mib.2004.04.002
DO - 10.1016/j.mib.2004.04.002
M3 - Article
SN - 1369-5274
VL - 7
SP - 308
EP - 313
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 3
ER -