Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction

G K Wagner; A M Riley; H J Rosenberg; C W Taylor; A H Guse; B V L Potter

Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction

G K Wagner
, A M Riley
, H J Rosenberg
, C W Taylor
, A H Guse
, B V L Potter

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (SciVal)

Abstract

Nicotinamide 8-Br-hypoxanthine dinucleotide (8-Br-NHD+) was cyclised at the N-1 position by ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose, a novel membrane-permeant analogue of cyclic-ADP ribose and agonist in human T cells. Adenine-substituted analogues of adenophostin A with potent Ca2+ releasing activity were synthesized; docking studies using the binding core of the Ins(1,4,5)P3 receptor identified specific residues that could be of importance in determining the hyperagonist nature of adenophostin activity.

Original language	English
Pages (from-to)	1-2
Number of pages	2
Journal	Nucleic Acids Research Supplement No.3
Publication status	Published - 2003

Cite this

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title = "Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction",

abstract = "Nicotinamide 8-Br-hypoxanthine dinucleotide (8-Br-NHD+) was cyclised at the N-1 position by ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose, a novel membrane-permeant analogue of cyclic-ADP ribose and agonist in human T cells. Adenine-substituted analogues of adenophostin A with potent Ca2+ releasing activity were synthesized; docking studies using the binding core of the Ins(1,4,5)P3 receptor identified specific residues that could be of importance in determining the hyperagonist nature of adenophostin activity.",

author = "Wagner, \{G K\} and Riley, \{A M\} and Rosenberg, \{H J\} and Taylor, \{C W\} and Guse, \{A H\} and Potter, \{B V L\}",

year = "2003",

language = "English",

pages = "1--2",

journal = "Nucleic Acids Research Supplement No.3",

issn = "1746-8272",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction

AU - Wagner, G K

AU - Riley, A M

AU - Rosenberg, H J

AU - Taylor, C W

AU - Guse, A H

AU - Potter, B V L

PY - 2003

Y1 - 2003

N2 - Nicotinamide 8-Br-hypoxanthine dinucleotide (8-Br-NHD+) was cyclised at the N-1 position by ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose, a novel membrane-permeant analogue of cyclic-ADP ribose and agonist in human T cells. Adenine-substituted analogues of adenophostin A with potent Ca2+ releasing activity were synthesized; docking studies using the binding core of the Ins(1,4,5)P3 receptor identified specific residues that could be of importance in determining the hyperagonist nature of adenophostin activity.

AB - Nicotinamide 8-Br-hypoxanthine dinucleotide (8-Br-NHD+) was cyclised at the N-1 position by ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose, a novel membrane-permeant analogue of cyclic-ADP ribose and agonist in human T cells. Adenine-substituted analogues of adenophostin A with potent Ca2+ releasing activity were synthesized; docking studies using the binding core of the Ins(1,4,5)P3 receptor identified specific residues that could be of importance in determining the hyperagonist nature of adenophostin activity.

M3 - Article

SN - 1746-8272

SP - 1

EP - 2

JO - Nucleic Acids Research Supplement No.3

JF - Nucleic Acids Research Supplement No.3

ER -

Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction

Abstract

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