Analogues of cyclic adenosine 5'-diphosphate ribose and adenophostin A, nucleotides in cellular signal transduction

G K Wagner, A M Riley, H J Rosenberg, C W Taylor, A H Guse, B V L Potter

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Nicotinamide 8-Br-hypoxanthine dinucleotide (8-Br-NHD+) was cyclised at the N-1 position by ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose, a novel membrane-permeant analogue of cyclic-ADP ribose and agonist in human T cells. Adenine-substituted analogues of adenophostin A with potent Ca2+ releasing activity were synthesized; docking studies using the binding core of the Ins(1,4,5)P3 receptor identified specific residues that could be of importance in determining the hyperagonist nature of adenophostin activity.
Original languageEnglish
Pages (from-to)1-2
Number of pages2
JournalNucleic Acids Research Supplement No.3
Publication statusPublished - 2003

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