An update on 2,5-Diketopiperazines from marine organisms

Ri Ming Huang, Xiang Xi Yi, Yuying Zhou, Xiangdong Su, Yan Peng, Cheng Hai Gao

Research output: Contribution to journalArticlepeer-review

79 Citations (SciVal)


2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms. Because of the increasing numbers and biological importance of these compounds, this review covers 90 marine originated 2,5-DKPs that were reported from 2009 to the first half-year of 2014. The review will focus on the structure characterizations, biological properties and proposed biosynthetic processes of these compounds.

Original languageEnglish
Pages (from-to)6213-6235
Number of pages23
JournalMarine Drugs
Issue number12
Publication statusPublished - 19 Dec 2014


  • 25-diketopiperazine
  • Biological activity
  • Biosynthetic processes
  • Marine organism


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