An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium

ENIGMA

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Abstract

BACKGROUND: Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.

METHOD: To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.

RESULTS: The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.

CONCLUSION: These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalPsychological Medicine
Early online date16 Oct 2019
DOIs
Publication statusE-pub ahead of print - 16 Oct 2019

Keywords

  • Aggression
  • cerebral cortical thinning
  • hostility
  • impulse control
  • positive symptoms
  • prospective meta-analysis
  • schizophrenia

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

@article{65c53d3b37234c9dbcd47b12f991e9df,
title = "An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium",
abstract = "BACKGROUND: Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.METHOD: To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.RESULTS: The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.CONCLUSION: These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.",
keywords = "Aggression, cerebral cortical thinning, hostility, impulse control, positive symptoms, prospective meta-analysis, schizophrenia",
author = "ENIGMA and Wong, {Ting Yat} and Joaquim Radua and Edith Pomarol-Clotet and Raymond Salvador and Anton Albajes-Eizagirre and Aleix Solanes and Canales-Rodriguez, {Erick J} and Amalia Guerrero-Pedraza and Salvador Sarro and Tilo Kircher and Igor Nenadic and Axel Krug and Dominik Grotegerd and Udo Dannlowski and Stefan Borgwardt and Anita Riecher-R{\"o}ssler and Andre Schmidt and Christina Andreou and Huber, {Christian G} and Jessica Turner and Vince Calhoun and Wenhao Jiang and Sarah Clark and Esther Walton and Gianfranco Spalletta and Nerisa Banaj and Fabrizio Piras and Valentina Ciullo and Daniela Vecchio and Irina Lebedeva and Tomyshev, {Alexander S} and Vasily Kaleda and Tatyana Klushnik and Filho, {Geraldo Busatto} and Zanetti, {Marcus Vinicius} and Serpa, {Mauricio Henriques} and {Penteado Rosa}, {Pedro Gomes} and Ryota Hashimoto and Masaki Fukunaga and Anja Richter and Bernd Kr{\"a}mer and Oliver Gruber and Voineskos, {Aristotle N} and Dickie, {Erin W} and David Tomecek and Antonin Skoch and Filip Spaniel and Cyril Hoschl and Alessandro Bertolino and Aurora Bonvino",
year = "2019",
month = "10",
day = "16",
doi = "10.1017/S0033291719002149",
language = "English",
pages = "1--12",
journal = "Psychological Medicine",
issn = "1469-8978",
publisher = "Cambridge University Press",

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T1 - An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium

AU - ENIGMA

AU - Wong, Ting Yat

AU - Radua, Joaquim

AU - Pomarol-Clotet, Edith

AU - Salvador, Raymond

AU - Albajes-Eizagirre, Anton

AU - Solanes, Aleix

AU - Canales-Rodriguez, Erick J

AU - Guerrero-Pedraza, Amalia

AU - Sarro, Salvador

AU - Kircher, Tilo

AU - Nenadic, Igor

AU - Krug, Axel

AU - Grotegerd, Dominik

AU - Dannlowski, Udo

AU - Borgwardt, Stefan

AU - Riecher-Rössler, Anita

AU - Schmidt, Andre

AU - Andreou, Christina

AU - Huber, Christian G

AU - Turner, Jessica

AU - Calhoun, Vince

AU - Jiang, Wenhao

AU - Clark, Sarah

AU - Walton, Esther

AU - Spalletta, Gianfranco

AU - Banaj, Nerisa

AU - Piras, Fabrizio

AU - Ciullo, Valentina

AU - Vecchio, Daniela

AU - Lebedeva, Irina

AU - Tomyshev, Alexander S

AU - Kaleda, Vasily

AU - Klushnik, Tatyana

AU - Filho, Geraldo Busatto

AU - Zanetti, Marcus Vinicius

AU - Serpa, Mauricio Henriques

AU - Penteado Rosa, Pedro Gomes

AU - Hashimoto, Ryota

AU - Fukunaga, Masaki

AU - Richter, Anja

AU - Krämer, Bernd

AU - Gruber, Oliver

AU - Voineskos, Aristotle N

AU - Dickie, Erin W

AU - Tomecek, David

AU - Skoch, Antonin

AU - Spaniel, Filip

AU - Hoschl, Cyril

AU - Bertolino, Alessandro

AU - Bonvino, Aurora

PY - 2019/10/16

Y1 - 2019/10/16

N2 - BACKGROUND: Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.METHOD: To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.RESULTS: The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.CONCLUSION: These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.

AB - BACKGROUND: Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.METHOD: To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.RESULTS: The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.CONCLUSION: These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.

KW - Aggression

KW - cerebral cortical thinning

KW - hostility

KW - impulse control

KW - positive symptoms

KW - prospective meta-analysis

KW - schizophrenia

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U2 - 10.1017/S0033291719002149

DO - 10.1017/S0033291719002149

M3 - Article

SP - 1

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JO - Psychological Medicine

JF - Psychological Medicine

SN - 1469-8978

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