TY - JOUR
T1 - An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium
AU - ENIGMA
AU - Wong, Ting Yat
AU - Radua, Joaquim
AU - Pomarol-Clotet, Edith
AU - Salvador, Raymond
AU - Albajes-Eizagirre, Anton
AU - Solanes, Aleix
AU - Canales-Rodriguez, Erick J
AU - Guerrero-Pedraza, Amalia
AU - Sarro, Salvador
AU - Kircher, Tilo
AU - Nenadic, Igor
AU - Krug, Axel
AU - Grotegerd, Dominik
AU - Dannlowski, Udo
AU - Borgwardt, Stefan
AU - Riecher-Rössler, Anita
AU - Schmidt, Andre
AU - Andreou, Christina
AU - Huber, Christian G
AU - Turner, Jessica
AU - Calhoun, Vince
AU - Jiang, Wenhao
AU - Clark, Sarah
AU - Walton, Esther
AU - Spalletta, Gianfranco
AU - Banaj, Nerisa
AU - Piras, Fabrizio
AU - Ciullo, Valentina
AU - Vecchio, Daniela
AU - Lebedeva, Irina
AU - Tomyshev, Alexander S
AU - Kaleda, Vasily
AU - Klushnik, Tatyana
AU - Filho, Geraldo Busatto
AU - Zanetti, Marcus Vinicius
AU - Serpa, Mauricio Henriques
AU - Penteado Rosa, Pedro Gomes
AU - Hashimoto, Ryota
AU - Fukunaga, Masaki
AU - Richter, Anja
AU - Krämer, Bernd
AU - Gruber, Oliver
AU - Voineskos, Aristotle N
AU - Dickie, Erin W
AU - Tomecek, David
AU - Skoch, Antonin
AU - Spaniel, Filip
AU - Hoschl, Cyril
AU - Bertolino, Alessandro
AU - Bonvino, Aurora
PY - 2020/9/30
Y1 - 2020/9/30
N2 - BACKGROUND: Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.METHOD: To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.RESULTS: The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.CONCLUSION: These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.
AB - BACKGROUND: Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.METHOD: To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.RESULTS: The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.CONCLUSION: These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.
KW - Aggression
KW - cerebral cortical thinning
KW - hostility
KW - impulse control
KW - positive symptoms
KW - prospective meta-analysis
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85073743434&partnerID=8YFLogxK
U2 - 10.1017/S0033291719002149
DO - 10.1017/S0033291719002149
M3 - Article
C2 - 31615588
SN - 1469-8978
VL - 50
SP - 2034
EP - 2045
JO - Psychological Medicine
JF - Psychological Medicine
IS - 12
ER -
