An organophosphorus(III)-Selective chemodosimeter for the ratiometric electrochemical detection of phosphines

Research output: Contribution to journalArticle

Abstract

The high toxicity of phosphine and the use of organophosphines as nerve agent precursors has provoked the requirement for a rapid and reliable detection methodology for their detection. Herein, we demonstrate that a ferrocene-derived molecular probe, armed with an azidobenzene trigger, delivers a ratiometric electrochemical signal selectively in response to organophosphorus(III) compounds and can be accurately measured with an inexpensive, handheld potentiostat. Through an intensive assay optimization process, conditions were found that could determine the presence of a model organophosphine(III) nerve agent precursor within minutes and achieved a limit of detection for triphenylphosphine of just 13 ppm. Due to the portability of the detection system and the excellent stability of the probe in solution, we envisaged that this proof-of-concept of work could easily be taken into the field to enable potentially toxic organophosphorus(III) compounds to be detected at the point-of-need.

Original languageEnglish
Article number19
JournalChemosensors
Volume7
Issue number2
DOIs
Publication statusPublished - 11 Apr 2019

Keywords

  • Electrochemical chemodosimeter
  • Phosphine detection
  • Point-of-use
  • Ratiometric sensing

ASJC Scopus subject areas

  • Analytical Chemistry
  • Physical and Theoretical Chemistry

Cite this

An organophosphorus(III)-Selective chemodosimeter for the ratiometric electrochemical detection of phosphines. / Spring, Sam A.; Goggins, Sean; Frost, Christopher G.

In: Chemosensors, Vol. 7, No. 2, 19, 11.04.2019.

Research output: Contribution to journalArticle

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