An extremely mild acetate pyrolysis reaction. Novel synthesis and x-ray structure determination of 1-azaspiro[5.5]undecane derivatives

Andrew B. Holmes, Paul R. Raithby, Keith Russell, Edward S. Stern, Michael E. Stubbs, Nicholas K. Wellard

Research output: Contribution to journalArticlepeer-review

Abstract

The azaspiro oxo-urethane (4), readily available from naphthalene, is reduced to the amino-alcohol (5) whose diacetate (6), the structure of which was determined by X-ray crystallography, undergoes acetate elimination in refluxing toluene to yield the N-acetylazaspiroundecene (7).

Original languageEnglish
Pages (from-to)1191-1192
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number17
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Molecular Medicine

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