TY - JOUR
T1 - An epigenome-wide association meta-analysis of prenatal maternal stress in neonates
AU - Rijlaarsdam, Jolien
AU - Pappa, Irene
AU - Walton, Esther
AU - Bakermans-Kranenburg, Marian J
AU - Mileva-Seitz, Viara R
AU - Rippe, Ralph C A
AU - Roza, Sabine J
AU - Jaddoe, Vincent W V
AU - Verhulst, Frank C
AU - Felix, Janine F
AU - Cecil, Charlotte A M
AU - Relton, Caroline L
AU - Gaunt, Tom R
AU - McArdle, Wendy
AU - Mill, Jonathan
AU - Barker, Edward D
AU - Tiemeier, Henning
AU - van IJzendoorn, Marinus H
PY - 2016/2
Y1 - 2016/2
N2 - Prenatal maternal stress exposure has been associated with neonatal differential DNA methylation. However, the available evidence in humans is largely based on candidate gene methylation studies, where only a few CpG sites were evaluated. The aim of this study was to examine the association between prenatal exposure to maternal stress and offspring genome-wide cord blood methylation using different methods. First, we conducted a meta-analysis and follow-up pathway analyses. Second, we used novel region discovery methods [i.e., differentially methylated regions (DMRs) analyses]. To this end, we used data from two independent population-based studies, the Generation R Study (n = 912) and the Avon Longitudinal Study of Parents and Children (ALSPAC, n = 828), to (i) measure genome-wide DNA methylation in cord blood and (ii) extract a prenatal maternal stress composite. The meta-analysis (ntotal = 1,740) revealed no epigenome-wide (meta P
AB - Prenatal maternal stress exposure has been associated with neonatal differential DNA methylation. However, the available evidence in humans is largely based on candidate gene methylation studies, where only a few CpG sites were evaluated. The aim of this study was to examine the association between prenatal exposure to maternal stress and offspring genome-wide cord blood methylation using different methods. First, we conducted a meta-analysis and follow-up pathway analyses. Second, we used novel region discovery methods [i.e., differentially methylated regions (DMRs) analyses]. To this end, we used data from two independent population-based studies, the Generation R Study (n = 912) and the Avon Longitudinal Study of Parents and Children (ALSPAC, n = 828), to (i) measure genome-wide DNA methylation in cord blood and (ii) extract a prenatal maternal stress composite. The meta-analysis (ntotal = 1,740) revealed no epigenome-wide (meta P
KW - Birth cohort
KW - cord blood
KW - DNA methylation
KW - epigenome-wide association study (EWAS)
KW - prenatal maternal stress
UR - https://www.scopus.com/pages/publications/84961392813
U2 - 10.1080/15592294.2016.1145329
DO - 10.1080/15592294.2016.1145329
M3 - Article
SN - 1559-2294
VL - 11
SP - 140
EP - 149
JO - Epigenetics
JF - Epigenetics
IS - 2
ER -