An epigenome-wide association meta-analysis of prenatal maternal stress in neonates

Jolien Rijlaarsdam; Irene Pappa; Esther Walton; Marian J Bakermans-Kranenburg; Viara R Mileva-Seitz; Ralph C A Rippe; Sabine J Roza; Vincent W V Jaddoe; Frank C Verhulst; Janine F Felix; Charlotte A M Cecil; Caroline L Relton; Tom R Gaunt; Wendy McArdle; Jonathan Mill; Edward D Barker; Henning Tiemeier; Marinus H van IJzendoorn

doi:10.1080/15592294.2016.1145329

An epigenome-wide association meta-analysis of prenatal maternal stress in neonates

Jolien Rijlaarsdam, Irene Pappa, Esther Walton, Marian J Bakermans-Kranenburg, Viara R Mileva-Seitz, Ralph C A Rippe, Sabine J Roza, Vincent W V Jaddoe, Frank C Verhulst, Janine F Felix, Charlotte A M Cecil, Caroline L Relton, Tom R Gaunt, Wendy McArdle, Jonathan Mill, Edward D Barker, Henning Tiemeier, Marinus H van IJzendoorn

Department of Psychology

Research output: Contribution to journal › Article › peer-review

74 Citations (SciVal)

Abstract

Prenatal maternal stress exposure has been associated with neonatal differential DNA methylation. However, the available evidence in humans is largely based on candidate gene methylation studies, where only a few CpG sites were evaluated. The aim of this study was to examine the association between prenatal exposure to maternal stress and offspring genome-wide cord blood methylation using different methods. First, we conducted a meta-analysis and follow-up pathway analyses. Second, we used novel region discovery methods [i.e., differentially methylated regions (DMRs) analyses]. To this end, we used data from two independent population-based studies, the Generation R Study (n = 912) and the Avon Longitudinal Study of Parents and Children (ALSPAC, n = 828), to (i) measure genome-wide DNA methylation in cord blood and (ii) extract a prenatal maternal stress composite. The meta-analysis (ntotal = 1,740) revealed no epigenome-wide (meta P

Original language	English
Pages (from-to)	140-149
Number of pages	10
Journal	Epigenetics
Volume	11
Issue number	2
DOIs	https://doi.org/10.1080/15592294.2016.1145329
Publication status	Published - Feb 2016

Keywords

Birth cohort
cord blood
DNA methylation
epigenome-wide association study (EWAS)
prenatal maternal stress

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10.1080/15592294.2016.1145329Licence: CC BY

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Rijlaarsdam, J., Pappa, I., Walton, E., Bakermans-Kranenburg, M. J., Mileva-Seitz, V. R., Rippe, R. C. A., Roza, S. J., Jaddoe, V. W. V., Verhulst, F. C., Felix, J. F., Cecil, C. A. M., Relton, C. L., Gaunt, T. R., McArdle, W., Mill, J., Barker, E. D., Tiemeier, H., & van IJzendoorn, M. H. (2016). An epigenome-wide association meta-analysis of prenatal maternal stress in neonates. Epigenetics, 11(2), 140-149. https://doi.org/10.1080/15592294.2016.1145329

Rijlaarsdam, J, Pappa, I, Walton, E, Bakermans-Kranenburg, MJ, Mileva-Seitz, VR, Rippe, RCA, Roza, SJ, Jaddoe, VWV, Verhulst, FC, Felix, JF, Cecil, CAM, Relton, CL, Gaunt, TR, McArdle, W, Mill, J, Barker, ED, Tiemeier, H & van IJzendoorn, MH 2016, 'An epigenome-wide association meta-analysis of prenatal maternal stress in neonates', Epigenetics, vol. 11, no. 2, pp. 140-149. https://doi.org/10.1080/15592294.2016.1145329

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abstract = "Prenatal maternal stress exposure has been associated with neonatal differential DNA methylation. However, the available evidence in humans is largely based on candidate gene methylation studies, where only a few CpG sites were evaluated. The aim of this study was to examine the association between prenatal exposure to maternal stress and offspring genome-wide cord blood methylation using different methods. First, we conducted a meta-analysis and follow-up pathway analyses. Second, we used novel region discovery methods [i.e., differentially methylated regions (DMRs) analyses]. To this end, we used data from two independent population-based studies, the Generation R Study (n = 912) and the Avon Longitudinal Study of Parents and Children (ALSPAC, n = 828), to (i) measure genome-wide DNA methylation in cord blood and (ii) extract a prenatal maternal stress composite. The meta-analysis (ntotal = 1,740) revealed no epigenome-wide (meta P ",

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AU - Mileva-Seitz, Viara R

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AU - Felix, Janine F

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AU - Relton, Caroline L

AU - Gaunt, Tom R

AU - McArdle, Wendy

AU - Mill, Jonathan

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An epigenome-wide association meta-analysis of prenatal maternal stress in neonates

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Keywords

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