This paper presents the results of investigations to determine how process settings and crimp geometry affect the seal strength and integrity of traditional polyolefin and biopolymer flexible packaging materials. The results show agreement with previous studies where temperature and dwell time are found to be the dominant factors for both polyolefin and biopolymer films. Pressure and crimp geometry are shown to be secondary factors in the process, up to the point of squeezing the film into molecular contact. In general it is shown that biopolymers exhibit similar sealing characteristics to more traditional films. In respect of the sealing crimp geometry it is shown that the crimp pitch has little or no effect on sealing integrity for films with gauges between 25µm and 40µm. But, for the same gauge material, crimp angles greater than 80° offer the greatest potential to gain higher seal strengths. It is further shown that with the cellulose and PLA films tested, a higher seal strength can be produced with crimp pitches of 2mm and lower. Also presented are some more general implications for guiding the selection of sealing crimp geometry and their usage with biopolymers.