An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential

M J Dixon; O A Andersen; D M F van Aalten; I M Eggleston

doi:10.1016/j.bmcl.2005.07.068

An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential

M J Dixon, O A Andersen, D M F van Aalten, I M Eggleston

Department of Life Sciences

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34 Citations (SciVal)

Abstract

The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.

Original language	English
Pages (from-to)	4717-4721
Number of pages	5
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	15
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2005.07.068
Publication status	Published - 2005

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10.1016/j.bmcl.2005.07.068

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title = "An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential",

abstract = "The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.",

author = "Dixon, \{M J\} and Andersen, \{O A\} and \{van Aalten\}, \{D M F\} and Eggleston, \{I M\}",

year = "2005",

doi = "10.1016/j.bmcl.2005.07.068",

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journal = "Bioorganic \& Medicinal Chemistry Letters",

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AU - Dixon, M J

AU - Andersen, O A

AU - van Aalten, D M F

AU - Eggleston, I M

PY - 2005

Y1 - 2005

N2 - The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.

AB - The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.

UR - http://dx.doi.org/10.1016/j.bmcl.2005.07.068

U2 - 10.1016/j.bmcl.2005.07.068

DO - 10.1016/j.bmcl.2005.07.068

M3 - Article

SN - 0960-894X

VL - 15

SP - 4717

EP - 4721

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 21

ER -

An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential

Abstract

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