An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential

M J Dixon, O A Andersen, D M F van Aalten, I M Eggleston

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.
Original languageEnglish
Pages (from-to)4717-4721
Number of pages5
JournalBioorganic & Medicinal Chemistry Letters
Volume15
Issue number21
DOIs
Publication statusPublished - 2005

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