An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy

L M A Rogers; P G McGivern; A R Butler; A J MacRobert; I M Eggleston

doi:10.1016/j.tet.2005.05.036

An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy

L M A Rogers
, P G McGivern
, A R Butler
, A J MacRobert
, I M Eggleston

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (SciVal)

Abstract

An efficient and cost-effective procedure has been devised for the preparation of urethane-protected 5-aminolaevulinic acid (5-ALA) dipeptide ester derivatives which avoids problems associated with the instability of 5-ALA under basic conditions. The procedure is also applicable to the direct synthesis of N-(α)-acetyl amino acid-ALA dipeptides in high enantiomeric purity as potential novel prodrugs for photodynamic therapy (PDT).

Original language	English
Pages (from-to)	6951-6958
Number of pages	8
Journal	Tetrahedron
Volume	61
DOIs	https://doi.org/10.1016/j.tet.2005.05.036
Publication status	Published - 2005

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10.1016/j.tet.2005.05.036

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title = "An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy",

abstract = "An efficient and cost-effective procedure has been devised for the preparation of urethane-protected 5-aminolaevulinic acid (5-ALA) dipeptide ester derivatives which avoids problems associated with the instability of 5-ALA under basic conditions. The procedure is also applicable to the direct synthesis of N-(α)-acetyl amino acid-ALA dipeptides in high enantiomeric purity as potential novel prodrugs for photodynamic therapy (PDT). ",

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T1 - An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy

AU - Rogers, L M A

AU - McGivern, P G

AU - Butler, A R

AU - MacRobert, A J

AU - Eggleston, I M

PY - 2005

Y1 - 2005

N2 - An efficient and cost-effective procedure has been devised for the preparation of urethane-protected 5-aminolaevulinic acid (5-ALA) dipeptide ester derivatives which avoids problems associated with the instability of 5-ALA under basic conditions. The procedure is also applicable to the direct synthesis of N-(α)-acetyl amino acid-ALA dipeptides in high enantiomeric purity as potential novel prodrugs for photodynamic therapy (PDT).

AB - An efficient and cost-effective procedure has been devised for the preparation of urethane-protected 5-aminolaevulinic acid (5-ALA) dipeptide ester derivatives which avoids problems associated with the instability of 5-ALA under basic conditions. The procedure is also applicable to the direct synthesis of N-(α)-acetyl amino acid-ALA dipeptides in high enantiomeric purity as potential novel prodrugs for photodynamic therapy (PDT).

U2 - 10.1016/j.tet.2005.05.036

DO - 10.1016/j.tet.2005.05.036

M3 - Article

SN - 0040-4020

VL - 61

SP - 6951

EP - 6958

JO - Tetrahedron

JF - Tetrahedron

ER -

An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy

Abstract

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