Abstract
An efficient six-step asymmetric synthesis of the cyclopropane containing natural product cascarillic acid in 41% overall yield is described. The key synthetic steps involve the use of a temporary stereogenic hydroxyl group to control the facial selectivity of a directed cyclopropanation reaction and its subsequent removal via a retro-aldol reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 1119-1121 |
| Number of pages | 3 |
| Journal | Synlett |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2006 |
Bibliographical note
ID number: ISI:000237436600030Fingerprint
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