An Approach to Derive Functional Peptide Inhibitors of Transcription Factor Activity

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• Active

  From Peptides to Mimetics: Towards Smaller More Stable Drug-like Protein-protein Interaction Inhibitors

  Mason, J. (PI)

  Biotechnology and Biological Sciences Research Council

  1/09/21 → 31/08/26

  Project: Research council

  • AP-1 Transcription Factor 100%
  • Malignant Neoplasm 86%
  • Transcription Factors 83%
  • Lactate Dehydrogenase 80%
  • DNA Binding 60%
• Finished

  Irreversibly Silencing Oncogenic Master-regulator cMyc Using Library-derived Electrophilic Helical Peptides

  Mason, J. (PI) & Van Den Elsen, J. (CoI)

  MRC

  1/12/20 → 30/11/24

  Project: Research council

  • Malignant Neoplasm 100%
  • Transcription Factors 80%
  • AP-1 Transcription Factor 68%
  • Peptide Library 64%
  • Cancer Cell 64%

• A Generalised Approach to Derive Functionally Active Peptide Inhibitors of Transcription Factor Activity

  Mason, J. (PI)

  Biotechnology and Biological Sciences Research Council

  1/10/18 → 30/06/22

  Project: Research council

  • AP-1 Transcription Factor 100%
  • Transcription Factors 80%
  • Peptide Library 59%
  • Transcription 51%
  • Signal Transduction 36%