TY - JOUR
T1 - An antimicrobial zinc based molecule for cross linking poly-acrylic acid
AU - James, Charlotte
AU - Pugh, Thomas
AU - Johnson, Andrew L
AU - Jenkins, A Toby A
PY - 2011
Y1 - 2011
N2 - A system for incorporating antimicrobial zinc into polymeric materials, in particular hydrogel type polymers has been developed. Zn(Bipy-(MMOES) 2) a zinc carboxylate monomer was designed with the purpose of mimicking commercial cross linking agents such as ethylene glycol diacrylate, as well as containing antimicrobial zinc ions (Zn2+), with the intention that it can be used to cross link into any polymeric material, the example here being polyacrylic acid. Two systems were studied: a homopolymer of the Zn(Bipy-(MMOES)2) and copolymers of Zn(Bipy-(MMOES)2) with acrylic acid (AA). The AA - Zn(Bipy-(MMOES)2) produced water swellable polymers which retained antimicrobial activity. The ability of the polymers to release the zinc ions was shown to be pH responsive and the leachate analysed to give a proposed mechanism of action. The Zn(Bipy-(MMOES) 2) monomer and polymers have shown antibacterial activity against both gram positive Methicillin susceptible staphylococcus aureus (MSSA 476) and gram negative Pseudomonas aeruginosa (PA01).
AB - A system for incorporating antimicrobial zinc into polymeric materials, in particular hydrogel type polymers has been developed. Zn(Bipy-(MMOES) 2) a zinc carboxylate monomer was designed with the purpose of mimicking commercial cross linking agents such as ethylene glycol diacrylate, as well as containing antimicrobial zinc ions (Zn2+), with the intention that it can be used to cross link into any polymeric material, the example here being polyacrylic acid. Two systems were studied: a homopolymer of the Zn(Bipy-(MMOES)2) and copolymers of Zn(Bipy-(MMOES)2) with acrylic acid (AA). The AA - Zn(Bipy-(MMOES)2) produced water swellable polymers which retained antimicrobial activity. The ability of the polymers to release the zinc ions was shown to be pH responsive and the leachate analysed to give a proposed mechanism of action. The Zn(Bipy-(MMOES) 2) monomer and polymers have shown antibacterial activity against both gram positive Methicillin susceptible staphylococcus aureus (MSSA 476) and gram negative Pseudomonas aeruginosa (PA01).
UR - http://www.scopus.com/inward/record.url?scp=79955900939&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1016/j.eurpolymj.2011.02.010
U2 - 10.1016/j.eurpolymj.2011.02.010
DO - 10.1016/j.eurpolymj.2011.02.010
M3 - Article
VL - 47
SP - 1338
EP - 1345
JO - European Polymer Journal
JF - European Polymer Journal
SN - 0014-3057
IS - 6
ER -