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An analgesiometry system for use in rabbits with some preliminary data on the effects of buprenorphine and lofentanil

  • R. Wootton
  • , G. Crosst
  • , S. Wood
  • , C. D. Westt
  • Imperial College NHS Healthcare Trust
  • Divisions of Comparative Medicine and Bioengineering

Research output: Contribution to journalArticlepeer-review

Abstract

A low cost infrared skin heating system has been designed to measure the efficacy of analgesics in rabbits. Following construction of a prototype, it was used to assess the effect of buprenorphine given subcutaneously and per rectum. Buprenorphine administered subcutaneously has a rapid onset of action, but its duration (8-10 h) appears slightly shorter than has been suggested previously; rectal administration appears to prolong its effect. Preliminary data show that lofentanil has a longer duration of action than buprenorphine and it may prove, therefore, to be a valuable long-acting analgesic in the rabbit.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalLaboratory Animals
Volume22
Issue number3
DOIs
Publication statusPublished - 1 Jul 1988

Keywords

  • ANALGESIOMETRY
  • BUPRENORPHINE
  • LOFENTANIL
  • RABBITS

ASJC Scopus subject areas

  • Animal Science and Zoology
  • General Veterinary

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