Amyloid formation by salmon calcitonin

P. J. Gilchrist, J. P. Bradshaw

Research output: Contribution to journalArticle

Abstract

It is demonstrated using three independent methods that salmon calcitonin can form amyloid fibrils in vitro. Large aggregates are shown to exhibit a blue-green birefringence in cross polarised light after staining with congo red. Individual fibrils were observed using electron microscopy. These fibrils are approx. 50-60 Å in diameter and up to 20 000 Å in length and are similar in appearance to those observed in Alzheimer's disease. Finally, X-ray diffraction studies of the large aggregates reveal the cross-β conformation characteristic of the monomers in the fibre.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalBBA - Molecular Basis of Disease
Volume1182
Issue number1
DOIs
Publication statusPublished - 4 Aug 1993

Keywords

  • Alzheimer's disease
  • Amyloid formation
  • Amyloid plaque
  • Calcitonin

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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