We report the rationallised design of aluminium initiators and their application for ROP of rac-lactide (rac-LA). Very minor change to the ligand backbone (imine reduction) to give secondary amines was found to have a dramatic effect on activity and selectivity with isotactic PLA being realised.
McKeown, P., Davidson, M. G., Kociok-Kohn, G., & Jones, M. D. (2016). Aluminium Salalens vs. Salans: “Initiator Design” for the Isoselective Polymerisation of rac-Lactide. Chemical Communications, 52(68), 10431-10434. https://doi.org/10.1039/C6CC05795K