During adolescence and puberty, alterations in pain, both experimental and clinical, are observed. In addition, adolescents undergo extensive biopsychosocial changes as they transition from childhood to adulthood. However, a better understanding of how the biopsychosocial changes during adolescence impact pain is needed to improve pain management and develop targeted pain interventions for adolescents. This review synthesizes the literature on alterations in pain during adolescence in humans, describes the potential biopsychosocial factors impacting pain during adolescence, and suggests future research directions to advance the understanding of the impact of adolescent development on pain.
Original languageEnglish
Pages (from-to)307-317
Number of pages11
JournalTrends in Neurosciences
Issue number4
Early online date24 Feb 2023
Publication statusPublished - 30 Apr 2023


  • biopsychosocial
  • brain
  • development
  • hormones
  • nociception
  • sex

ASJC Scopus subject areas

  • Neuroscience(all)


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