Allosteric interaction of metal ions with saccharides in a crowned diboronic acid

Gang Deng; Tony D James; Seiji Shinkai

doi:10.1021/ja00090a004

Allosteric interaction of metal ions with saccharides in a crowned diboronic acid

Gang Deng, Tony D James, Seiji Shinkai

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.

Original language	English
Pages (from-to)	4567-4572
Number of pages	6
Journal	Journal of the American Chemical Society
Volume	116
Issue number	11
DOIs	https://doi.org/10.1021/ja00090a004
Publication status	Published - 1994

Access to Document

10.1021/ja00090a004

Cite this

@article{54dc8c5044c4463989441f43ea140526,

title = "Allosteric interaction of metal ions with saccharides in a crowned diboronic acid",

abstract = "A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.",

author = "Gang Deng and James, \{Tony D\} and Seiji Shinkai",

year = "1994",

doi = "10.1021/ja00090a004",

language = "English",

volume = "116",

pages = "4567--4572",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - Allosteric interaction of metal ions with saccharides in a crowned diboronic acid

AU - Deng, Gang

AU - James, Tony D

AU - Shinkai, Seiji

PY - 1994

Y1 - 1994

N2 - A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.

AB - A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.

UR - http://dx.doi.org/10.1021/ja00090a004

UR - https://www.scopus.com/pages/publications/84954820170

U2 - 10.1021/ja00090a004

DO - 10.1021/ja00090a004

M3 - Article

SN - 0002-7863

VL - 116

SP - 4567

EP - 4572

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 11

ER -

Allosteric interaction of metal ions with saccharides in a crowned diboronic acid

Abstract

Access to Document

Other files and links

Fingerprint

Cite this