Allosteric interaction of metal ions with saccharides in a crowned diboronic acid

Gang Deng; Tony D James; Seiji Shinkai

doi:10.1021/ja00090a004

Allosteric interaction of metal ions with saccharides in a crowned diboronic acid

Gang Deng, Tony D James, Seiji Shinkai

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.

Original language	English
Pages (from-to)	4567-4572
Number of pages	6
Journal	Journal of the American Chemical Society
Volume	116
Issue number	11
DOIs	https://doi.org/10.1021/ja00090a004
Publication status	Published - 1994

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title = "Allosteric interaction of metal ions with saccharides in a crowned diboronic acid",

abstract = "A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.",

author = "Gang Deng and James, {Tony D} and Seiji Shinkai",

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N2 - A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.

AB - A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.

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DO - 10.1021/ja00090a004

M3 - Article

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EP - 4572

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 11

ER -

Allosteric interaction of metal ions with saccharides in a crowned diboronic acid

Abstract

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