Allosteric interaction of metal ions with saccharides in a crowned diboronic acid

Gang Deng, Tony D James, Seiji Shinkai

Research output: Contribution to journalArticle


A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are successfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.
Original languageEnglish
Pages (from-to)4567-4572
Number of pages6
JournalJournal of the American Chemical Society
Issue number11
Publication statusPublished - 1994


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