Aggregation-Induced Emission (AIE), Life and Health

Haoran Wang, Qiyao Li, Parvej Alam, Haotian Bai, Vandana Bhalla, Martin R. Bryce, Mingyue Cao, Chao Chen, Sijie Chen, Xirui Chen, Yuncong Chen, Zhijun Chen, Dongfeng Dang, Dan Ding, Siyang Ding, Yanhong Duo, Meng Gao, Wei He, Xuewen He, Xuechuan HongYuning Hong, Jing Jing Hu, Rong Hu, Xiaolin Huang, Tony D. James, Xingyu Jiang, Gen Ichi Konishi, Ryan T.K. Kwok, Jacky W.Y. Lam, Chunbin Li, Haidong Li, Kai Li, Nan Li, Wei Jian Li, Ying Li, Xing Jie Liang, Yongye Liang, Bin Liu, Guozhen Liu, Xingang Liu, Xiaoding Lou, Xin Yue Lou, Liang Luo, Paul R. McGonigal, Zong Wan Mao, Guangle Niu, Tze Cin Owyong, Andrea Pucci, Jun Qian, Anjun Qin, Zijie Qiu, Andrey L. Rogach, Bo Situ, Kazuo Tanaka, Youhong Tang, Bingnan Wang, Dong Wang, Jianguo Wang, Wei Wang, Wen Xiong Wang, Wen Jin Wang, Xinyuan Wang, Yi Feng Wang, Shuizhu Wu, Yifan Wu, Yonghua Xiong, Ruohan Xu, Chenxu Yan, Saisai Yan, Hai Bo Yang, Lin Lin Yang, Mingwang Yang, Ying Wei Yang, Juyoung Yoon, Shuang Quan Zang, Jiangjiang Zhang, Pengfei Zhang, Tianfu Zhang, Xin Zhang, Xin Zhang, Na Zhao, Zheng Zhao, Jie Zheng, Lei Zheng, Zheng Zheng, Ming Qiang Zhu, Wei Hong Zhu, Hang Zou, Ben Zhong Tang

Research output: Contribution to journalReview articlepeer-review

52 Citations (SciVal)


Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.

Original languageEnglish
Pages (from-to)14347-14405
Number of pages59
JournalACS Nano
Issue number15
Early online date24 Jul 2023
Publication statusPublished - 8 Aug 2023

Bibliographical note

The authors are grateful for the funding support from the National Natural Science Foundation of China (21788102, 21877021, 32160661, 52003228), the Research Grants Council of Hong Kong (C6014-20W), the Innovation and Technology Commission (ITC-CNERC14SC01), Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ2021324134613038, GJHZ20210705141810031), Shenzhen Key Laboratory of Functional Aggregate Materials (ZDSYS20211021111400001), the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China (2019B030301003), the Project funded by China Postdoctoral Science Foundation (2022M72308), the National Natural Science Foundation of China (62105184), the National Natural Science Foundation of China (Grant no. 21871108), NSF-2107619, Faculty Summer Fellowship from The University of Akron, the National Natural Science Foundation of China (32172296), and Japan Society for the Promotion of Science (the MEXT/JSPS KAKENHI grants 23H02036 and 17H05145).


  • aggregation-induced emission
  • bioimaging
  • biomedical application
  • combined therapy
  • detection
  • luminescent material
  • monitoring
  • phototheranostics
  • precision medicine

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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