Aggregation-Induced Emission (AIE), Life and Health

Haoran Wang; Qiyao Li; Parvej Alam; Haotian Bai; Vandana Bhalla; Martin R. Bryce; Mingyue Cao; Chao Chen; Sijie Chen; Xirui Chen; Yuncong Chen; Zhijun Chen; Dongfeng Dang; Dan Ding; Siyang Ding; Yanhong Duo; Meng Gao; Wei He; Xuewen He; Xuechuan Hong; Yuning Hong; Jing Jing Hu; Rong Hu; Xiaolin Huang; Tony D. James; Xingyu Jiang; Gen Ichi Konishi; Ryan T.K. Kwok; Jacky W.Y. Lam; Chunbin Li; Haidong Li; Kai Li; Nan Li; Wei Jian Li; Ying Li; Xing Jie Liang; Yongye Liang; Bin Liu; Guozhen Liu; Xingang Liu; Xiaoding Lou; Xin Yue Lou; Liang Luo; Paul R. McGonigal; Zong Wan Mao; Guangle Niu; Tze Cin Owyong; Andrea Pucci; Jun Qian; Anjun Qin; Zijie Qiu; Andrey L. Rogach; Bo Situ; Kazuo Tanaka; Youhong Tang; Bingnan Wang; Dong Wang; Jianguo Wang; Wei Wang; Wen Xiong Wang; Wen Jin Wang; Xinyuan Wang; Yi Feng Wang; Shuizhu Wu; Yifan Wu; Yonghua Xiong; Ruohan Xu; Chenxu Yan; Saisai Yan; Hai Bo Yang; Lin Lin Yang; Mingwang Yang; Ying Wei Yang; Juyoung Yoon; Shuang Quan Zang; Jiangjiang Zhang; Pengfei Zhang; Tianfu Zhang; Xin Zhang; Xin Zhang; Na Zhao; Zheng Zhao; Jie Zheng; Lei Zheng; Zheng Zheng; Ming Qiang Zhu; Wei Hong Zhu; Hang Zou; Ben Zhong Tang

doi:10.1021/acsnano.3c03925

Aggregation-Induced Emission (AIE), Life and Health

Haoran Wang, Qiyao Li, Parvej Alam, Haotian Bai, Vandana Bhalla, Martin R. Bryce, Mingyue Cao, Chao Chen, Sijie Chen, Xirui Chen, Yuncong Chen, Zhijun Chen, Dongfeng Dang, Dan Ding, Siyang Ding, Yanhong Duo, Meng Gao, Wei He, Xuewen He, Xuechuan HongYuning Hong, Jing Jing Hu, Rong Hu, Xiaolin Huang, Tony D. James, Xingyu Jiang, Gen Ichi Konishi, Ryan T.K. Kwok, Jacky W.Y. Lam, Chunbin Li, Haidong Li, Kai Li, Nan Li, Wei Jian Li, Ying Li, Xing Jie Liang, Yongye Liang, Bin Liu, Guozhen Liu, Xingang Liu, Xiaoding Lou, Xin Yue Lou, Liang Luo, Paul R. McGonigal, Zong Wan Mao, Guangle Niu, Tze Cin Owyong, Andrea Pucci, Jun Qian, Anjun Qin, Zijie Qiu, Andrey L. Rogach, Bo Situ, Kazuo Tanaka, Youhong Tang, Bingnan Wang, Dong Wang, Jianguo Wang, Wei Wang, Wen Xiong Wang, Wen Jin Wang, Xinyuan Wang, Yi Feng Wang, Shuizhu Wu, Yifan Wu, Yonghua Xiong, Ruohan Xu, Chenxu Yan, Saisai Yan, Hai Bo Yang, Lin Lin Yang, Mingwang Yang, Ying Wei Yang, Juyoung Yoon, Shuang Quan Zang, Jiangjiang Zhang, Pengfei Zhang, Tianfu Zhang, Xin Zhang, Xin Zhang, Na Zhao, Zheng Zhao, Jie Zheng, Lei Zheng, Zheng Zheng, Ming Qiang Zhu, Wei Hong Zhu, Hang Zou, Ben Zhong Tang

Research output: Contribution to journal › Review article › peer-review

105 Citations (SciVal)

Abstract

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.

Original language	English
Pages (from-to)	14347-14405
Number of pages	59
Journal	ACS Nano
Volume	17
Issue number	15
Early online date	24 Jul 2023
DOIs	https://doi.org/10.1021/acsnano.3c03925
Publication status	Published - 8 Aug 2023

Bibliographical note

The authors are grateful for the funding support from the National Natural Science Foundation of China (21788102, 21877021, 32160661, 52003228), the Research Grants Council of Hong Kong (C6014-20W), the Innovation and Technology Commission (ITC-CNERC14SC01), Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ2021324134613038, GJHZ20210705141810031), Shenzhen Key Laboratory of Functional Aggregate Materials (ZDSYS20211021111400001), the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China (2019B030301003), the Project funded by China Postdoctoral Science Foundation (2022M72308), the National Natural Science Foundation of China (62105184), the National Natural Science Foundation of China (Grant no. 21871108), NSF-2107619, Faculty Summer Fellowship from The University of Akron, the National Natural Science Foundation of China (32172296), and Japan Society for the Promotion of Science (the MEXT/JSPS KAKENHI grants 23H02036 and 17H05145).

Funding

The authors are grateful for the funding support from the National Natural Science Foundation of China (21788102, 21877021, 32160661, 52003228), the Research Grants Council of Hong Kong (C6014-20W), the Innovation and Technology Commission (ITC-CNERC14SC01), Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ2021324134613038, GJHZ20210705141810031), Shenzhen Key Laboratory of Functional Aggregate Materials (ZDSYS20211021111400001), the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China (2019B030301003), the Project funded by China Postdoctoral Science Foundation (2022M72308), the National Natural Science Foundation of China (62105184), the National Natural Science Foundation of China (Grant no. 21871108), NSF-2107619, Faculty Summer Fellowship from The University of Akron, the National Natural Science Foundation of China (32172296), and Japan Society for the Promotion of Science (the MEXT/JSPS KAKENHI grants 23H02036 and 17H05145).

Funders	Funder number
Shenzhen Key Laboratory of Functional Aggregate Materials	ZDSYS20211021111400001
University of Akron	32172296
Japan Society for the Promotion of Science	17H05145, 23H02036
Ministry of Education, Culture, Sports, Science and Technology
National Natural Science Foundation of China	32160661, 52003228, 21877021, 21788102
China Postdoctoral Science Foundation	NSF-2107619, 62105184, 2022M72308, 21871108
Research Grants Council, University Grants Committee	C6014-20W
Innovation and Technology Commission	ITC-CNERC14SC01
South China University of Technology	2019B030301003
Science, Technology and Innovation Commission of Shenzhen Municipality	GJHZ20210705141810031, JCYJ2021324134613038

Keywords

aggregation-induced emission
bioimaging
biomedical application
combined therapy
detection
luminescent material
monitoring
phototheranostics
precision medicine

ASJC Scopus subject areas

General Materials Science
General Engineering
General Physics and Astronomy

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10.1021/acsnano.3c03925Licence: CC BY

Cite this

Wang, H, Li, Q, Alam, P, Bai, H, Bhalla, V, Bryce, MR, Cao, M, Chen, C, Chen, S, Chen, X, Chen, Y, Chen, Z, Dang, D, Ding, D, Ding, S, Duo, Y, Gao, M, He, W, He, X, Hong, X, Hong, Y, Hu, JJ, Hu, R, Huang, X, James, TD, Jiang, X, Konishi, GI, Kwok, RTK, Lam, JWY, Li, C, Li, H, Li, K, Li, N, Li, WJ, Li, Y, Liang, XJ, Liang, Y, Liu, B, Liu, G, Liu, X, Lou, X, Lou, XY, Luo, L, McGonigal, PR, Mao, ZW, Niu, G, Owyong, TC, Pucci, A, Qian, J, Qin, A, Qiu, Z, Rogach, AL, Situ, B, Tanaka, K, Tang, Y, Wang, B, Wang, D, Wang, J, Wang, W, Wang, WX, Wang, WJ, Wang, X, Wang, YF, Wu, S, Wu, Y, Xiong, Y, Xu, R, Yan, C, Yan, S, Yang, HB, Yang, LL, Yang, M, Yang, YW, Yoon, J, Zang, SQ, Zhang, J, Zhang, P, Zhang, T, Zhang, X, Zhang, X, Zhao, N, Zhao, Z, Zheng, J, Zheng, L, Zheng, Z, Zhu, MQ, Zhu, WH, Zou, H & Tang, BZ 2023, 'Aggregation-Induced Emission (AIE), Life and Health', ACS Nano, vol. 17, no. 15, pp. 14347-14405. https://doi.org/10.1021/acsnano.3c03925

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title = "Aggregation-Induced Emission (AIE), Life and Health",

abstract = "Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.",

keywords = "aggregation-induced emission, bioimaging, biomedical application, combined therapy, detection, luminescent material, monitoring, phototheranostics, precision medicine",

author = "Haoran Wang and Qiyao Li and Parvej Alam and Haotian Bai and Vandana Bhalla and Bryce, {Martin R.} and Mingyue Cao and Chao Chen and Sijie Chen and Xirui Chen and Yuncong Chen and Zhijun Chen and Dongfeng Dang and Dan Ding and Siyang Ding and Yanhong Duo and Meng Gao and Wei He and Xuewen He and Xuechuan Hong and Yuning Hong and Hu, {Jing Jing} and Rong Hu and Xiaolin Huang and James, {Tony D.} and Xingyu Jiang and Konishi, {Gen Ichi} and Kwok, {Ryan T.K.} and Lam, {Jacky W.Y.} and Chunbin Li and Haidong Li and Kai Li and Nan Li and Li, {Wei Jian} and Ying Li and Liang, {Xing Jie} and Yongye Liang and Bin Liu and Guozhen Liu and Xingang Liu and Xiaoding Lou and Lou, {Xin Yue} and Liang Luo and McGonigal, {Paul R.} and Mao, {Zong Wan} and Guangle Niu and Owyong, {Tze Cin} and Andrea Pucci and Jun Qian and Anjun Qin and Zijie Qiu and Rogach, {Andrey L.} and Bo Situ and Kazuo Tanaka and Youhong Tang and Bingnan Wang and Dong Wang and Jianguo Wang and Wei Wang and Wang, {Wen Xiong} and Wang, {Wen Jin} and Xinyuan Wang and Wang, {Yi Feng} and Shuizhu Wu and Yifan Wu and Yonghua Xiong and Ruohan Xu and Chenxu Yan and Saisai Yan and Yang, {Hai Bo} and Yang, {Lin Lin} and Mingwang Yang and Yang, {Ying Wei} and Juyoung Yoon and Zang, {Shuang Quan} and Jiangjiang Zhang and Pengfei Zhang and Tianfu Zhang and Xin Zhang and Xin Zhang and Na Zhao and Zheng Zhao and Jie Zheng and Lei Zheng and Zheng Zheng and Zhu, {Ming Qiang} and Zhu, {Wei Hong} and Hang Zou and Tang, {Ben Zhong}",

note = "The authors are grateful for the funding support from the National Natural Science Foundation of China (21788102, 21877021, 32160661, 52003228), the Research Grants Council of Hong Kong (C6014-20W), the Innovation and Technology Commission (ITC-CNERC14SC01), Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ2021324134613038, GJHZ20210705141810031), Shenzhen Key Laboratory of Functional Aggregate Materials (ZDSYS20211021111400001), the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China (2019B030301003), the Project funded by China Postdoctoral Science Foundation (2022M72308), the National Natural Science Foundation of China (62105184), the National Natural Science Foundation of China (Grant no. 21871108), NSF-2107619, Faculty Summer Fellowship from The University of Akron, the National Natural Science Foundation of China (32172296), and Japan Society for the Promotion of Science (the MEXT/JSPS KAKENHI grants 23H02036 and 17H05145).",

year = "2023",

month = aug,

day = "8",

doi = "10.1021/acsnano.3c03925",

language = "English",

volume = "17",

pages = "14347--14405",

journal = "ACS Nano",

issn = "1936-0851",

publisher = "American Chemical Society",

number = "15",

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T1 - Aggregation-Induced Emission (AIE), Life and Health

AU - Wang, Haoran

AU - Li, Qiyao

AU - Alam, Parvej

AU - Bai, Haotian

AU - Bhalla, Vandana

AU - Bryce, Martin R.

AU - Cao, Mingyue

AU - Chen, Chao

AU - Chen, Sijie

AU - Chen, Xirui

AU - Chen, Yuncong

AU - Chen, Zhijun

AU - Dang, Dongfeng

AU - Ding, Dan

AU - Ding, Siyang

AU - Duo, Yanhong

AU - Gao, Meng

AU - He, Wei

AU - He, Xuewen

AU - Hong, Xuechuan

AU - Hong, Yuning

AU - Hu, Jing Jing

AU - Hu, Rong

AU - Huang, Xiaolin

AU - James, Tony D.

AU - Jiang, Xingyu

AU - Konishi, Gen Ichi

AU - Kwok, Ryan T.K.

AU - Lam, Jacky W.Y.

AU - Li, Chunbin

AU - Li, Haidong

AU - Li, Kai

AU - Li, Nan

AU - Li, Wei Jian

AU - Li, Ying

AU - Liang, Xing Jie

AU - Liang, Yongye

AU - Liu, Bin

AU - Liu, Guozhen

AU - Liu, Xingang

AU - Lou, Xiaoding

AU - Lou, Xin Yue

AU - Luo, Liang

AU - McGonigal, Paul R.

AU - Mao, Zong Wan

AU - Niu, Guangle

AU - Owyong, Tze Cin

AU - Pucci, Andrea

AU - Qian, Jun

AU - Qin, Anjun

AU - Qiu, Zijie

AU - Rogach, Andrey L.

AU - Situ, Bo

AU - Tanaka, Kazuo

AU - Tang, Youhong

AU - Wang, Bingnan

AU - Wang, Dong

AU - Wang, Jianguo

AU - Wang, Wei

AU - Wang, Wen Xiong

AU - Wang, Wen Jin

AU - Wang, Xinyuan

AU - Wang, Yi Feng

AU - Wu, Shuizhu

AU - Wu, Yifan

AU - Xiong, Yonghua

AU - Xu, Ruohan

AU - Yan, Chenxu

AU - Yan, Saisai

AU - Yang, Hai Bo

AU - Yang, Lin Lin

AU - Yang, Mingwang

AU - Yang, Ying Wei

AU - Yoon, Juyoung

AU - Zang, Shuang Quan

AU - Zhang, Jiangjiang

AU - Zhang, Pengfei

AU - Zhang, Tianfu

AU - Zhang, Xin

AU - Zhao, Na

AU - Zhao, Zheng

AU - Zheng, Jie

AU - Zheng, Lei

AU - Zheng, Zheng

AU - Zhu, Ming Qiang

AU - Zhu, Wei Hong

AU - Zou, Hang

AU - Tang, Ben Zhong

N1 - The authors are grateful for the funding support from the National Natural Science Foundation of China (21788102, 21877021, 32160661, 52003228), the Research Grants Council of Hong Kong (C6014-20W), the Innovation and Technology Commission (ITC-CNERC14SC01), Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ2021324134613038, GJHZ20210705141810031), Shenzhen Key Laboratory of Functional Aggregate Materials (ZDSYS20211021111400001), the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China (2019B030301003), the Project funded by China Postdoctoral Science Foundation (2022M72308), the National Natural Science Foundation of China (62105184), the National Natural Science Foundation of China (Grant no. 21871108), NSF-2107619, Faculty Summer Fellowship from The University of Akron, the National Natural Science Foundation of China (32172296), and Japan Society for the Promotion of Science (the MEXT/JSPS KAKENHI grants 23H02036 and 17H05145).

PY - 2023/8/8

Y1 - 2023/8/8

N2 - Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.

AB - Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health.

KW - aggregation-induced emission

KW - bioimaging

KW - biomedical application

KW - combined therapy

KW - detection

KW - luminescent material

KW - monitoring

KW - phototheranostics

KW - precision medicine

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M3 - Review article

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AN - SCOPUS:85167475154

SN - 1936-0851

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JO - ACS Nano

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ER -

Aggregation-Induced Emission (AIE), Life and Health

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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