Abstract
Purpose: The health-related quality of life (HRQoL) of patients completing multidrug-resistant tuberculosis (MDR-TB) treatment in Namibia and whether the occurrence of adverse events influenced patients’ rating of their HRQoL was evaluated. Patients and methods: A cross-sectional analytic survey of patients completing or who recently completed MDR-TB treatment was conducted. The patients rated their HRQoL using the simplified Short Form-8™ (SF-8) questionnaire consisting of eight Likert-type questions. Three supplemental questions on the adverse events that the patients may have experienced during their MDR-TB treatment were also included. Scoring of HRQoL ratings was norm-based (mean =50, standard deviation =10) ranging from 20 (worst health) to 80 (best health), rather than the conventional 0-100 scores. We evaluated the internal consistency of the scale items using the Cronbach’s alpha, performed descriptive analyses, and analyzed the association between the patients’ HRQoL scores and adverse events. Results: Overall, 36 patients (20 males, 56%) aged 17-54 years (median =40 years) responded to the questionnaire. The median (range) HRQoL score for the physical component summary was 58.6 (35.3-60.5), while the median score for the mental component summary was 59.3 (26.6-61.9), indicating not-so-high self-rating of health. There was good internal consistency of the scale scores, with a Cronbach’s alpha value of.0.80. In all, 32 (89%) of the 36 patients experienced at least one adverse drug event of any severity during their treatment (median events =3, range 1-6), of which none was life-threatening. The occurrence of adverse events was not related to HRQoL scores. For patients reporting zero to two events, the median (range) HRQoL score was 56.8 (44.4-56.8), while for those reporting three or more events, the median score was 55.2 (38.6-56.8); P=0.34 for difference between these scores. Conclusion: Patients completing treatment for MDR-TB in Namibia tended to score moderately low on their HRQoL, using the generic SF-8 questionnaire. The occurrence of adverse events did not lead to lower HRQoL scores upon treatment completion.
| Original language | English |
|---|---|
| Pages (from-to) | 2369-2377 |
| Number of pages | 9 |
| Journal | Patient Preference and Adherence |
| Volume | 10 |
| DOIs | |
| Publication status | Published - 23 Nov 2016 |
Bibliographical note
Funding Information:Table I contains a classification of the static analysis methods that were useful in the detection of IMSL errors and the number of errors for which each method was effective. The asterisks denote errors whose discovery by the associated Permission to copy without fee all or part of this material is granted provided that the copies are not made or distributed for direct commercial advantage, the ACM copyright notice and the title of the publication and its date appear, and notice is given that copying is by permission of the Association for Computing Machinery. To copy otherwise, or to republish, requires a fee and/or specific permission. This research was supported by the U.S. National Bureau of Standards and by the National Research Council of Canada. Author's address: Department of Mathematics, University of Victoria, P.O. Box 1700, Victoria, British Columbia, Canada V8W 2Y2. © 1980 ACM 0164-0925/80/0700-0307 $00.75 ACM Transactionso n ProgrammingL anguagesa nd Systems, Vol. 2, No. 3, July 1980, Pages 307-320
Keywords
- Drug safety
- Namibia
- Patient-reported health outcomes
- Second-line tuberculosis drugs
- SF-8™ questionnaire
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Social Sciences (miscellaneous)
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Health Policy
