Advances in multi-target fluorescent probes for imaging and analyzing biomarkers in Alzheimer’s disease

Chaofeng Zhu, Jiahao Han, Fanghui Liang, Mingguang Zhu, Guoyang Zhang, Tony James, Zhuo Wang

Research output: Contribution to journalReview articlepeer-review


Alzheimer’s disease (AD) is a neurodegenerative condition that poses multiple challenges for disease diagnosis and treatment. Biomarker-based assays are one of the important tools for the early diagnosis of AD. In recent years, researchers have pursued the development of fluorescent probes for multi-target analysis of AD biomarkers. Herein, we review representative fluorescent probes for multi-target analysis, including analysis of Aβ and viscosity, Aβ and reactive oxygen species, various proteins (NFTs, Aβ aggregates, or Aβ oligomers), and multi-modal imaging. We discuss the advantages and disadvantages of the reported probes and summarize the achievements, current challenges, and application prospects for multi-target fluorescent probes in AD.

Original languageEnglish
Article number216002
JournalCoordination Chemistry Reviews
Early online date20 Jun 2024
Publication statusE-pub ahead of print - 20 Jun 2024

Data Availability Statement

No data was used for the research described in the article.

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