Advances in multi-target fluorescent probes for imaging and analyzing biomarkers in Alzheimer’s disease

Chaofeng Zhu; Jiahao Han; Fanghui Liang; Mingguang Zhu; Guoyang Zhang; Tony James; Zhuo Wang

doi:10.1016/j.ccr.2024.216002

Advances in multi-target fluorescent probes for imaging and analyzing biomarkers in Alzheimer’s disease

Chaofeng Zhu, Jiahao Han, Fanghui Liang, Mingguang Zhu, Guoyang Zhang, Tony James, Zhuo Wang

Research output: Contribution to journal › Review article › peer-review

Abstract

Alzheimer’s disease (AD) is a neurodegenerative condition that poses multiple challenges for disease diagnosis and treatment. Biomarker-based assays are one of the important tools for the early diagnosis of AD. In recent years, researchers have pursued the development of fluorescent probes for multi-target analysis of AD biomarkers. Herein, we review representative fluorescent probes for multi-target analysis, including analysis of Aβ and viscosity, Aβ and reactive oxygen species, various proteins (NFTs, Aβ aggregates, or Aβ oligomers), and multi-modal imaging. We discuss the advantages and disadvantages of the reported probes and summarize the achievements, current challenges, and application prospects for multi-target fluorescent probes in AD.

Original language	English
Article number	216002
Journal	Coordination Chemistry Reviews
Volume	517
Early online date	20 Jun 2024
DOIs	https://doi.org/10.1016/j.ccr.2024.216002
Publication status	Published - 15 Oct 2024

Data Availability Statement

No data was used for the research described in the article.

Funding

We are thankful for support from Beijing Natural Science Foundation (no. 7232342), the National Key Research and Development Program of China (2021YFC2101500), Academy of Medical Sciences Newton Advanced Fellowship (NAFR13\\1015). The Natural Science Foundation of China (no. 82131430174, 81961138011), TDJ wishes to thank the University of Bath and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University (2020ZD01) for support.

Funders	Funder number
University of Bath
National Key Research and Development Program of China	2021YFC2101500
National Natural Science Foundation of China	82131430174, 81961138011
Henan Normal University	2020ZD01
Academy of Medical Sciences-Newton	NAFR13\1015
Natural Science Foundation of Beijing Municipality	7232342

Keywords

Alzheimer's disease
Fluorescent probes
Multi-target analysis
β-Amyloid

ASJC Scopus subject areas

General Chemistry
Materials Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry

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10.1016/j.ccr.2024.216002Licence: CC BY

Cite this

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abstract = "Alzheimer{\textquoteright}s disease (AD) is a neurodegenerative condition that poses multiple challenges for disease diagnosis and treatment. Biomarker-based assays are one of the important tools for the early diagnosis of AD. In recent years, researchers have pursued the development of fluorescent probes for multi-target analysis of AD biomarkers. Herein, we review representative fluorescent probes for multi-target analysis, including analysis of Aβ and viscosity, Aβ and reactive oxygen species, various proteins (NFTs, Aβ aggregates, or Aβ oligomers), and multi-modal imaging. We discuss the advantages and disadvantages of the reported probes and summarize the achievements, current challenges, and application prospects for multi-target fluorescent probes in AD.",

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AU - Zhu, Chaofeng

AU - Han, Jiahao

AU - Liang, Fanghui

AU - Zhu, Mingguang

AU - Zhang, Guoyang

AU - James, Tony

AU - Wang, Zhuo

PY - 2024/10/15

Y1 - 2024/10/15

N2 - Alzheimer’s disease (AD) is a neurodegenerative condition that poses multiple challenges for disease diagnosis and treatment. Biomarker-based assays are one of the important tools for the early diagnosis of AD. In recent years, researchers have pursued the development of fluorescent probes for multi-target analysis of AD biomarkers. Herein, we review representative fluorescent probes for multi-target analysis, including analysis of Aβ and viscosity, Aβ and reactive oxygen species, various proteins (NFTs, Aβ aggregates, or Aβ oligomers), and multi-modal imaging. We discuss the advantages and disadvantages of the reported probes and summarize the achievements, current challenges, and application prospects for multi-target fluorescent probes in AD.

AB - Alzheimer’s disease (AD) is a neurodegenerative condition that poses multiple challenges for disease diagnosis and treatment. Biomarker-based assays are one of the important tools for the early diagnosis of AD. In recent years, researchers have pursued the development of fluorescent probes for multi-target analysis of AD biomarkers. Herein, we review representative fluorescent probes for multi-target analysis, including analysis of Aβ and viscosity, Aβ and reactive oxygen species, various proteins (NFTs, Aβ aggregates, or Aβ oligomers), and multi-modal imaging. We discuss the advantages and disadvantages of the reported probes and summarize the achievements, current challenges, and application prospects for multi-target fluorescent probes in AD.

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KW - Fluorescent probes

KW - Multi-target analysis

KW - β-Amyloid

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Advances in multi-target fluorescent probes for imaging and analyzing biomarkers in Alzheimer’s disease

Abstract

Data Availability Statement

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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