Advances in anti-BRAF therapies for lung cancer

Giandomenico Roviello, Alberto D'Angelo, Marianna Sirico, Matteo Pittacolo, Felipe Umpierre Conter, Navid Sobhani

Research output: Contribution to journalReview articlepeer-review

2 Citations (SciVal)

Abstract

Non-small cell lung cancer (NSCLC) is one of the most frequent causes of mortality in the western world. v-raf murine sarcoma viral oncogene homolog B (BRAF) is a member of the Raf kinase family and plays a critical role in cellular growth, proliferation, and differentiation through the mitogen-activated protein kinase pathway. The incidence of BRAF mutations in NSCLC is low, accounting for 0-3% of all cases of lung cancer. Given the results obtained in metastatic melanoma, several studies have reported the efficacy of anti-BRAF therapies in NSCLC treatment. In this review, we describe changes in the landscape of BRAF-mutated lung cancer treatment and analyze insights from major clinical trials in the context of future therapeutic prospects.

Original languageEnglish
Pages (from-to)879-890
Number of pages12
JournalInvestigational New Drugs
Volume39
Issue number3
Early online date21 Jan 2021
DOIs
Publication statusPublished - 30 Jun 2021

Keywords

  • BRAF
  • Lung cancer
  • V600

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)

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