Advanced microscopy techniques to assess solid-state properties of inhalation medicines

Jagdeep Shur, Robert Price

Research output: Contribution to journalArticlepeer-review

19 Citations (SciVal)
279 Downloads (Pure)


Efficient control and characterisation of the physico-chemical properties of active pharmaceutical ingredients (APIs) and excipients for orally inhaled drug products (OIDPs) are critical to successful product development. Control and reduction of risk require the introduction of a material science based approach to product development and the use of advanced analytical tools in understanding how the solid-state properties of the input materials influence structure and product functionality. The key issues to be addressed, at a microscopic scale, are understanding how the critical quality attributes of input materials influence surface, interfacial and particulate interactions within OIDPs. This review offers an in-depth discussion on the use of advanced microscopy techniques in characterising of the solid-state properties of particulate materials for OIDPs. The review covers the fundamental principles of the techniques, instrumentation types, data interpretation and specific applications in relation to the product development of OIDPs.
Original languageEnglish
Pages (from-to)369-382
Number of pages14
JournalAdvanced Drug Delivery Reviews
Issue number4
Publication statusPublished - 30 Mar 2012


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