Adipose Tissue Dysfunction

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Abstract

The impairment of normal adipose tissue function; characterized by changes to the structure and cellular composition of the tissue microenvironment, resulting in abnormal secretions derived predominantly, but not exclusively, from adipocytes (i.e., fat cells) and localized immune cells. These changes can be instigated by energy imbalance and are commonly observed with aging and obesity. The result is expansion of abdominal subcutaneous and visceral (intra-abdominal) adipose tissue, but for women especially, gluteofemoral (hip and legs) adipose stores. The broader consequences are local and systemic inflammation, impaired tissue-specific and whole-body insulin sensitivity, and poor metabolic control. Thus, adipose tissue dysfunction is implicated in the pathogenesis of type-II diabetes, hypertension, cancer, cognitive dysfunction, and atherosclerosis.
Original languageEnglish
Title of host publicationEncyclopedia of Behavioral Medicine
Place of PublicationNew York, U. S. A.
PublisherSpringer
Pages1-5
ISBN (Electronic)9781461464396
DOIs
Publication statusPublished - 2018

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Trim, W., Thompson, D., & Turner, J. E. (2018). Adipose Tissue Dysfunction. In Encyclopedia of Behavioral Medicine (pp. 1-5). New York, U. S. A.: Springer. https://doi.org/10.1007/978-1-4614-6439-6_101903-1