Addressing unmet needs in understanding asthma mechanisms

Michael Edwards, Sejal Saglani, Jurgen Schwarze, Chrysanthi Skevaki, Jaclyn Smith, Ben Ainsworth, Mark Almond, Evangelos Andreakos, Maria Belvisi, Kian Fan Chung, William Cookson, Paul Cullinan, Catherine Hawrylowicz, Marek Lommatzsch, David Jackson, Rene Lutter, Benjamin Marsland, Miriam Moffat, Mike Thomas, J. Christian VirchowGeorgina Xanthou, Jessica Edwards, Samantha Walker, Sebastian L. Johnston, EARIP WP2 Working Group

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Abstract

Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.
Original languageEnglish
Article number1602448
Pages (from-to)1-43
Number of pages43
JournalEuropean Respiratory Journal
Volume49
Issue number5
Early online date1 May 2017
DOIs
Publication statusPublished - 1 May 2017

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    Edwards, M., Saglani, S., Schwarze, J., Skevaki, C., Smith, J., Ainsworth, B., Almond, M., Andreakos, E., Belvisi, M., Chung, K. F., Cookson, W., Cullinan, P., Hawrylowicz, C., Lommatzsch, M., Jackson, D., Lutter, R., Marsland, B., Moffat, M., Thomas, M., ... Group, EARIP. WP. W. (2017). Addressing unmet needs in understanding asthma mechanisms. European Respiratory Journal, 49(5), 1-43. [1602448]. https://doi.org/10.1183/13993003.02448-2016