TY - JOUR
T1 - Additively manufactured ferroelectric particulate composites for antimicrobial applications
AU - Tsikriteas, Zois Michail
AU - Heylen, Rachel
AU - Jindal, Swati
AU - Mancuso, Elena
AU - Li, Zihe
AU - Khanbareh, Hamideh
N1 - EPSRC
Engineering and Physical Sciences Research Council
DST Innovations Ltd
Annette Trust
PY - 2023/3/11
Y1 - 2023/3/11
N2 - A polarized ferroelectric material can initiate the micro electrolysis of water molecules which leads to the formation of reactive oxygen species (ROS) in an aqueous solution resulting in selective bacteria killing. This study presents the fabrication, characterization, and antimicrobial performance of poled ferroelectric particulate composites. Barium calcium zirconate titanate (BCZT) micro-powder was synthesized by a solid-state reaction and mechanically mixed with polycaprolactone (PCL) to be subsequently fed into the 3D bioprinter for the fabrication of porous PCL-BCZT structures at four different ceramic loadings (0%, 10%, 20%, 30% wt.). For the examination of material's capacity to handle extremely high contamination, the composites were exposed to a high inoculum of bacteria (Escherichia coli ATCC 25922). Approximately 70% of Escherichia coli degradation was recorded at the end of 15 minutes without any external intervention. The surface selective bacterial degradation can be attributed to the generated reactive oxygen species (ROS), the large surface area of the porous samples and polymer matrix’s hydrophobic nature, behaviour which can be reflected in the composites with 30 wt% of BCZT loading exhibiting the best antimicrobial performance among the other state-of-the-art ferroelectrics. Overall, these results indicate that the poled composites have a great potential as antimicrobial materials and surfaces.
AB - A polarized ferroelectric material can initiate the micro electrolysis of water molecules which leads to the formation of reactive oxygen species (ROS) in an aqueous solution resulting in selective bacteria killing. This study presents the fabrication, characterization, and antimicrobial performance of poled ferroelectric particulate composites. Barium calcium zirconate titanate (BCZT) micro-powder was synthesized by a solid-state reaction and mechanically mixed with polycaprolactone (PCL) to be subsequently fed into the 3D bioprinter for the fabrication of porous PCL-BCZT structures at four different ceramic loadings (0%, 10%, 20%, 30% wt.). For the examination of material's capacity to handle extremely high contamination, the composites were exposed to a high inoculum of bacteria (Escherichia coli ATCC 25922). Approximately 70% of Escherichia coli degradation was recorded at the end of 15 minutes without any external intervention. The surface selective bacterial degradation can be attributed to the generated reactive oxygen species (ROS), the large surface area of the porous samples and polymer matrix’s hydrophobic nature, behaviour which can be reflected in the composites with 30 wt% of BCZT loading exhibiting the best antimicrobial performance among the other state-of-the-art ferroelectrics. Overall, these results indicate that the poled composites have a great potential as antimicrobial materials and surfaces.
KW - Antimicrobial ferroelectrics
KW - PCL
KW - BCZT
KW - Piezoelectric scaffolds
KW - 3D printing
U2 - 10.1002/admt.202202127
DO - 10.1002/admt.202202127
M3 - Article
SN - 2365-709X
JO - Advanced Materials Technologies
JF - Advanced Materials Technologies
ER -