Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

Doyin Odunmbaku-Mansell; V. D.  Bruno; Eva Sammut; Amedeo Chiribiri; Thomas Johnson; I Khaliulin; Daniel Baz Lopez; H S Gill; Katharine Fraser; M Murphy; T Krieg; M. S. Suleiman; S George; Raimondo Ascione; Andrew Cookson

doi:10.1038/s41598-021-97834-y

Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

Doyin Odunmbaku-Mansell, V. D. Bruno, Eva Sammut, Amedeo Chiribiri, Thomas Johnson, I Khaliulin, Daniel Baz Lopez, H S Gill, Katharine Fraser, M Murphy, T Krieg, M. S. Suleiman, S George, Raimondo Ascione, Andrew Cookson

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Abstract

To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5–6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5–6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.

Original language	English
Article number	18322
Journal	Scientific Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-97834-y
Publication status	Published - 15 Sept 2021

Bibliographical note

Funding Information:
This work was supported by a Great West 4 (GW4) Initiator grant to Ascione (GW4-AF4-011) and partially by the University of Bath. In addition, this work was supported by the following grants to Ascione: Medical Research Council (MRC): MR/L012723/1; British Heart Foundation (BHF): IG/14/2/30991, PG/10/40/28369, PG/07/046/22772, and PG/16/104/32652) to Ascione, and by a Developmental Pathway Funding Scheme (DPFS) grant to Murphy, Krieg and Ascione (MR/M015769/1). Mansell was supported by an EPSRC DTP.

Funding Information:
The authors would like to thank the staff at the University of Bristol Translational Biomedical Research Centre, a national research facility for large animal co-funded by the British Heart Foundation and the Medical Research Council.

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus subject areas

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s41598-021-97834-yFinal published version, 2.6 MBLicence: CC BY

Cite this

Odunmbaku-Mansell, D., Bruno, V. D., Sammut, E., Chiribiri, A., Johnson, T., Khaliulin, I., Baz Lopez, D., Gill, H. S., Fraser, K., Murphy, M., Krieg, T., Suleiman, M. S., George, S., Ascione, R., & Cookson, A. (2021). Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model. Scientific Reports, 11(1), Article 18322. https://doi.org/10.1038/s41598-021-97834-y

Odunmbaku-Mansell, D, Bruno, VD, Sammut, E, Chiribiri, A, Johnson, T, Khaliulin, I, Baz Lopez, D, Gill, HS , Fraser, K, Murphy, M, Krieg, T, Suleiman, MS, George, S, Ascione, R & Cookson, A 2021, 'Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model', Scientific Reports, vol. 11, no. 1, 18322. https://doi.org/10.1038/s41598-021-97834-y

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title = "Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model",

abstract = "To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5–6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5–6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.",

author = "Doyin Odunmbaku-Mansell and Bruno, {V. D.} and Eva Sammut and Amedeo Chiribiri and Thomas Johnson and I Khaliulin and {Baz Lopez}, Daniel and Gill, {H S} and Katharine Fraser and M Murphy and T Krieg and Suleiman, {M. S.} and S George and Raimondo Ascione and Andrew Cookson",

note = "Funding Information: This work was supported by a Great West 4 (GW4) Initiator grant to Ascione (GW4-AF4-011) and partially by the University of Bath. In addition, this work was supported by the following grants to Ascione: Medical Research Council (MRC): MR/L012723/1; British Heart Foundation (BHF): IG/14/2/30991, PG/10/40/28369, PG/07/046/22772, and PG/16/104/32652) to Ascione, and by a Developmental Pathway Funding Scheme (DPFS) grant to Murphy, Krieg and Ascione (MR/M015769/1). Mansell was supported by an EPSRC DTP. Funding Information: The authors would like to thank the staff at the University of Bristol Translational Biomedical Research Centre, a national research facility for large animal co-funded by the British Heart Foundation and the Medical Research Council. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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AU - Odunmbaku-Mansell, Doyin

AU - Bruno, V. D.

AU - Sammut, Eva

AU - Chiribiri, Amedeo

AU - Johnson, Thomas

AU - Khaliulin, I

AU - Baz Lopez, Daniel

AU - Gill, H S

AU - Fraser, Katharine

AU - Murphy, M

AU - Krieg, T

AU - Suleiman, M. S.

AU - George, S

AU - Ascione, Raimondo

AU - Cookson, Andrew

N1 - Funding Information: This work was supported by a Great West 4 (GW4) Initiator grant to Ascione (GW4-AF4-011) and partially by the University of Bath. In addition, this work was supported by the following grants to Ascione: Medical Research Council (MRC): MR/L012723/1; British Heart Foundation (BHF): IG/14/2/30991, PG/10/40/28369, PG/07/046/22772, and PG/16/104/32652) to Ascione, and by a Developmental Pathway Funding Scheme (DPFS) grant to Murphy, Krieg and Ascione (MR/M015769/1). Mansell was supported by an EPSRC DTP. Funding Information: The authors would like to thank the staff at the University of Bristol Translational Biomedical Research Centre, a national research facility for large animal co-funded by the British Heart Foundation and the Medical Research Council. Publisher Copyright: © 2021, The Author(s).

PY - 2021/9/15

Y1 - 2021/9/15

N2 - To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5–6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5–6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.

AB - To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5–6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5–6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.

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Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

Abstract

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Myocardial Infarction Project

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Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

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Fingerprint

Projects

Myocardial Infarction Project

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