Acute Exercise as an Adjuvant to Influenza Vaccination

Acute exercise prior to vaccine administration can improve the immune response. Animal data are now supported by human trials, which have shown that immune responses are enhanced by a bout of acute exercise before innoculation; this effect is particularly prominent in vaccines that normally produce weak immune responses. Although there remain many aspects of this phenomenon to be investigated, including task characteristics such as duration and form of exercise, it appears that even a moderate bout of exercise of the muscles into which vaccine will be administered can enhance the antibody response. In this review, the authors will summarize the animal and human literature and discuss the investigation of potential mechanisms of acute exerciseã¢â‚¬â€œinduced immunoenhancement.