Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

Daniel D. Sanz Sharley; Jonathan M J Williams

doi:10.1039/c6cc09023k

Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

Daniel D. Sanz Sharley
, Jonathan M J Williams

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Abstract

We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 °C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 °C.

Original language	English
Pages (from-to)	2020-2023
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	12
Early online date	21 Nov 2016
DOIs	https://doi.org/10.1039/c6cc09023k
Publication status	Published - 11 Feb 2017

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abstract = "We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol\% afforded acetamide products in excellent yields at temperatures ranging from 80-120 °C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 °C.",

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N2 - We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 °C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 °C.

AB - We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 °C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 °C.

UR - https://www.scopus.com/pages/publications/85011933773

UR - http://dx.doi.org/10.1039/c6cc09023k

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DO - 10.1039/c6cc09023k

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JO - Chemical Communications

JF - Chemical Communications

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Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

Abstract

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