Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

Daniel D. Sanz Sharley, Jonathan M J Williams

Research output: Contribution to journalArticle

22 Citations (Scopus)
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Abstract

We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 °C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 °C.

Original languageEnglish
Pages (from-to)2020-2023
Number of pages4
JournalChemical Communications
Volume53
Issue number12
Early online date21 Nov 2016
DOIs
Publication statusPublished - 11 Feb 2017

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Formamides
Acetylation
Acylation
Amides
Acetic acid
Acetic Acid
Amines
Esters
Catalysts
Temperature
ethyl acetate
butyl acetate
acetamide

Cite this

Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source. / Sanz Sharley, Daniel D.; Williams, Jonathan M J.

In: Chemical Communications, Vol. 53, No. 12, 11.02.2017, p. 2020-2023.

Research output: Contribution to journalArticle

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