Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

Daniel D. Sanz Sharley, Jonathan M J Williams

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We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 °C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 °C.

Original languageEnglish
Pages (from-to)2020-2023
Number of pages4
JournalChemical Communications
Issue number12
Early online date21 Nov 2016
Publication statusPublished - 11 Feb 2017


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