TY - JOUR
T1 - Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source
AU - Sanz Sharley, Daniel D.
AU - Williams, Jonathan M J
PY - 2017/2/11
Y1 - 2017/2/11
N2 - We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 °C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 °C.
AB - We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80-120 °C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 °C.
UR - http://www.scopus.com/inward/record.url?scp=85011933773&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1039/c6cc09023k
U2 - 10.1039/c6cc09023k
DO - 10.1039/c6cc09023k
M3 - Article
AN - SCOPUS:85011933773
SN - 1359-7345
VL - 53
SP - 2020
EP - 2023
JO - Chemical Communications
JF - Chemical Communications
IS - 12
ER -