Accessibility of spoken, written, and sign language in Landau-Kleffner syndrome: a linguistic and functional MRI study

J. S. Sieratzki, G. A. Calvert, M. Brammer, A. David, B. Woll

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Landau-Kleffner syndrome (LKS) is an acquired aphasia which begins in childhood and is thought to arise from an epileptic disorder within the auditory speech cortex. Although the epilepsy usually subsides at puberty, a severe communication impairment often persists. Here Lye report on a detailed study of a 26-year old, left-handed male, with onset of LKS at age 5 years, who is aphasic for English but who learned British Sign Language (BSL) at age 13. We have investigated his skills in different language modalities, recorded EEGs during wakefulness, sleep, and under conditions of auditory stimulation, measured brain stem auditory-evoked potentials (BAEP), and performed functional MRI (fMRI) during a range of linguistic tasks. Our investigation demonstrated severe restrictions in comprehension and production of spoken English as well as lip-reading, while reading was comparatively less impaired. BSL was by far the most efficient mode of communication. All EEG recordings were normal, while BAEP showed minor abnormalities, fMRI revealed: 1) powerful and extensive bilateral (R > L) activation of auditory cortices in response to heard speech, much stronger than when listening to music; 2) very little response to silent lip-reading; 3) strong activation in the temporo-parieto-occipital association cortex, exclusively in the right hemisphere (RH), when viewing BSL signs. Analysis of these findings provides novel insights into the disturbance of the auditory speech cortex which underlies LKS and its diagnostic evaluation by fMRI, and underpins a strategy of restoring communication abilities in LKS through a natural sign language of the deal (with Video).
Original languageEnglish
Pages (from-to)79-89
Number of pages11
JournalEpileptic Disorders
Volume3
Issue number2
Publication statusPublished - 2001

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Landau-Kleffner Syndrome
Sign Language
Linguistics
Auditory Cortex
Magnetic Resonance Imaging
Lipreading
Brain Stem Auditory Evoked Potentials
Communication
Electroencephalography
Lye
Acoustic Stimulation
Occipital Lobe
Aptitude
Wakefulness
Aphasia
Puberty
Music
Reading
Epilepsy
Sleep

Cite this

Sieratzki, J. S., Calvert, G. A., Brammer, M., David, A., & Woll, B. (2001). Accessibility of spoken, written, and sign language in Landau-Kleffner syndrome: a linguistic and functional MRI study. Epileptic Disorders, 3(2), 79-89.

Accessibility of spoken, written, and sign language in Landau-Kleffner syndrome : a linguistic and functional MRI study. / Sieratzki, J. S.; Calvert, G. A.; Brammer, M.; David, A.; Woll, B.

In: Epileptic Disorders, Vol. 3, No. 2, 2001, p. 79-89.

Research output: Contribution to journalArticle

Sieratzki, JS, Calvert, GA, Brammer, M, David, A & Woll, B 2001, 'Accessibility of spoken, written, and sign language in Landau-Kleffner syndrome: a linguistic and functional MRI study', Epileptic Disorders, vol. 3, no. 2, pp. 79-89.
Sieratzki, J. S. ; Calvert, G. A. ; Brammer, M. ; David, A. ; Woll, B. / Accessibility of spoken, written, and sign language in Landau-Kleffner syndrome : a linguistic and functional MRI study. In: Epileptic Disorders. 2001 ; Vol. 3, No. 2. pp. 79-89.
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