Accelerating innovations in C[sbnd]H activation/functionalization through intricately designed magnetic nanomaterials: From genesis to applicability in liquid/regio/photo catalysis

Selective functionalization of highly inert and ubiquitous C[sbnd]H bonds that would provide a ready access to synthetically valuable motifs has perplexed the chemists since long. Also, environmental benignity and economic viability have been the prime factors driving tremendous interest in C[sbnd]H functionalization. This has led to many inspiring discoveries infuriating the development of potent catalytic systems that enable the facile replacement of the C[sbnd]H bonds with conventional functional groups, allowing the construction of C-C, C-N, C-O, C-S, C-B and C-halogen bonds at both sp² as well as sp³ centres. In fact, catalytic C[sbnd]H functionalization strategies integrating the benefits of magnetic recovery have emerged as sustainable gateway for affording a diverse array of transformations. This review sheds light on the remarkable advancements witnessed in this area as a consequence of integrating the inherent magnetism of catalysts with the cutting-edge direct C[sbnd]H functionalization strategy. Also, the promising future perspectives comprehensively covered in this review is anticipated to motivate the academic and industrial researchers, arousing their creativity for designing competent sustainable strategies to generate a plethora of pharmaceutically active molecules.