Abnormal cardiac enzymes in systemic sclerosis

A report of four patients and review of the literature

B. Vasta, V. Flower, C. Bucciarelli-Ducci, S. Brown, E. Korendowych, N.J. McHugh, J.D. Pauling

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cardiac involvement in systemic sclerosis (SSc) is heterogeneous and can include primary involvement of the myocardium, pericardium and coronary arteries or be secondary to cardiac complications of pulmonary and renal disease. Primary cardiac involvement in SSc is uncommon but can result in ventricular dysfunction, organ failure, arrhythmias and death. It can remain clinically silent and the prevalence is likely to be under-reported. We report four cases of SSc associated with a raised serum troponin T (TnT), in a proportion of whom cardiac MRI myocardial abnormalities were detected. These cases highlight the heterogeneity of cardiac involvement in SSc, the role of cardiac MRI and promising biochemical responses to immunosuppression. Cardiac biomarkers such as TnT may be useful screening tools to identify subclinical cardiac disease and assess response to therapeutic intervention.
Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalClinical Rheumatology
Volume33
Issue number3
Early online date3 Oct 2013
DOIs
Publication statusPublished - Mar 2014

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Systemic Scleroderma
Troponin T
Enzymes
Ventricular Dysfunction
Pericardium
Immunosuppression
Lung Diseases
Cardiac Arrhythmias
Heart Diseases
Coronary Vessels
Myocardium
Biomarkers
Kidney
Serum
Therapeutics

Cite this

Abnormal cardiac enzymes in systemic sclerosis : A report of four patients and review of the literature. / Vasta, B.; Flower, V.; Bucciarelli-Ducci, C.; Brown, S.; Korendowych, E.; McHugh, N.J.; Pauling, J.D.

In: Clinical Rheumatology, Vol. 33, No. 3, 03.2014, p. 435-438.

Research output: Contribution to journalArticle

Vasta, B. ; Flower, V. ; Bucciarelli-Ducci, C. ; Brown, S. ; Korendowych, E. ; McHugh, N.J. ; Pauling, J.D. / Abnormal cardiac enzymes in systemic sclerosis : A report of four patients and review of the literature. In: Clinical Rheumatology. 2014 ; Vol. 33, No. 3. pp. 435-438.
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