8 Citations (Scopus)
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Abstract

A new and superior one-filtration method for the determination of the molecular weight cut-off (MWCO) of aqueous based nanofiltration and ultrafiltration membranes has been developed using the widest range of polyethylene glycol oligomers as MWCO probes of any MWCO method so far. This method was enabled by a new, high resolution oligomer separation and detection using high performance liquid chromatography (HPLC) coupled with an evaporative light scattering detector (ELSD). The refined method can determine the MWCO of membranes over a MW range from 678 to 4594 g mol−1 with a molecular weight difference of just 44 g mol−1 and a bonus further one point extension to 6000 g mol−1 – giving the widest range and most precise difference of MWs that can be resolved of any single filtration MWCO method that exists. MWCO determination of five commercial membranes from GE Osmonics™ and Millipore showed good agreement with manufacturer and literature values, confirming the accuracy of the method. As this new method has significant advantages over all other existing aqueous MWCO determinations (i.e. single filtration, higher resolution over a wider MW range, low cost MWCO molecular probes), it is suggested that it could be adopted as the new standard for determining aqueous MWCO over a MW range from 678 to 6000 g mol−1.
Original languageEnglish
Pages (from-to)304-311
Number of pages8
JournalJournal of Membrane Science
Volume525
Early online date6 Dec 2016
DOIs
Publication statusPublished - 1 Mar 2017

Fingerprint

Nanofiltration
Ultrafiltration
molecular weight
cut-off
Molecular Weight
Molecular weight
membranes
Membranes
high resolution
oligomers
Oligomers
Molecular Probes
probes
liquid chromatography
High performance liquid chromatography
Light scattering
Polyethylene glycols
glycols
polyethylenes
light scattering

Keywords

  • Molecular weight cut-off
  • MWCO
  • Polyethylene glycol
  • High performance liquid chromatography
  • Evaporative light scattering detection
  • Aqueous membrane filtration
  • Nanofiltration
  • Ultrafiltration

ASJC Scopus subject areas

  • Filtration and Separation
  • Analytical Chemistry

Cite this

@article{469a4600bba24c56a48f285ce835df08,
title = "A wide range and high resolution one-filtration molecular weight cut-off method for aqueous based nanofiltration and ultrafiltration membranes",
abstract = "A new and superior one-filtration method for the determination of the molecular weight cut-off (MWCO) of aqueous based nanofiltration and ultrafiltration membranes has been developed using the widest range of polyethylene glycol oligomers as MWCO probes of any MWCO method so far. This method was enabled by a new, high resolution oligomer separation and detection using high performance liquid chromatography (HPLC) coupled with an evaporative light scattering detector (ELSD). The refined method can determine the MWCO of membranes over a MW range from 678 to 4594 g mol−1 with a molecular weight difference of just 44 g mol−1 and a bonus further one point extension to 6000 g mol−1 – giving the widest range and most precise difference of MWs that can be resolved of any single filtration MWCO method that exists. MWCO determination of five commercial membranes from GE Osmonics™ and Millipore showed good agreement with manufacturer and literature values, confirming the accuracy of the method. As this new method has significant advantages over all other existing aqueous MWCO determinations (i.e. single filtration, higher resolution over a wider MW range, low cost MWCO molecular probes), it is suggested that it could be adopted as the new standard for determining aqueous MWCO over a MW range from 678 to 6000 g mol−1.",
keywords = "Molecular weight cut-off, MWCO, Polyethylene glycol, High performance liquid chromatography, Evaporative light scattering detection, Aqueous membrane filtration, Nanofiltration, Ultrafiltration",
author = "Lili Xu and Salman Shahid and Junjie Shen and Emanuelsson, {Emma A.C.} and Darrell Patterson",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.memsci.2016.12.004",
language = "English",
volume = "525",
pages = "304--311",
journal = "Journal of Membrane Science",
issn = "0376-7388",
publisher = "Elsevier",

}

TY - JOUR

T1 - A wide range and high resolution one-filtration molecular weight cut-off method for aqueous based nanofiltration and ultrafiltration membranes

AU - Xu, Lili

AU - Shahid, Salman

AU - Shen, Junjie

AU - Emanuelsson, Emma A.C.

AU - Patterson, Darrell

PY - 2017/3/1

Y1 - 2017/3/1

N2 - A new and superior one-filtration method for the determination of the molecular weight cut-off (MWCO) of aqueous based nanofiltration and ultrafiltration membranes has been developed using the widest range of polyethylene glycol oligomers as MWCO probes of any MWCO method so far. This method was enabled by a new, high resolution oligomer separation and detection using high performance liquid chromatography (HPLC) coupled with an evaporative light scattering detector (ELSD). The refined method can determine the MWCO of membranes over a MW range from 678 to 4594 g mol−1 with a molecular weight difference of just 44 g mol−1 and a bonus further one point extension to 6000 g mol−1 – giving the widest range and most precise difference of MWs that can be resolved of any single filtration MWCO method that exists. MWCO determination of five commercial membranes from GE Osmonics™ and Millipore showed good agreement with manufacturer and literature values, confirming the accuracy of the method. As this new method has significant advantages over all other existing aqueous MWCO determinations (i.e. single filtration, higher resolution over a wider MW range, low cost MWCO molecular probes), it is suggested that it could be adopted as the new standard for determining aqueous MWCO over a MW range from 678 to 6000 g mol−1.

AB - A new and superior one-filtration method for the determination of the molecular weight cut-off (MWCO) of aqueous based nanofiltration and ultrafiltration membranes has been developed using the widest range of polyethylene glycol oligomers as MWCO probes of any MWCO method so far. This method was enabled by a new, high resolution oligomer separation and detection using high performance liquid chromatography (HPLC) coupled with an evaporative light scattering detector (ELSD). The refined method can determine the MWCO of membranes over a MW range from 678 to 4594 g mol−1 with a molecular weight difference of just 44 g mol−1 and a bonus further one point extension to 6000 g mol−1 – giving the widest range and most precise difference of MWs that can be resolved of any single filtration MWCO method that exists. MWCO determination of five commercial membranes from GE Osmonics™ and Millipore showed good agreement with manufacturer and literature values, confirming the accuracy of the method. As this new method has significant advantages over all other existing aqueous MWCO determinations (i.e. single filtration, higher resolution over a wider MW range, low cost MWCO molecular probes), it is suggested that it could be adopted as the new standard for determining aqueous MWCO over a MW range from 678 to 6000 g mol−1.

KW - Molecular weight cut-off

KW - MWCO

KW - Polyethylene glycol

KW - High performance liquid chromatography

KW - Evaporative light scattering detection

KW - Aqueous membrane filtration

KW - Nanofiltration

KW - Ultrafiltration

UR - http://dx.doi.org/10.1016/j.memsci.2016.12.004

U2 - 10.1016/j.memsci.2016.12.004

DO - 10.1016/j.memsci.2016.12.004

M3 - Article

VL - 525

SP - 304

EP - 311

JO - Journal of Membrane Science

JF - Journal of Membrane Science

SN - 0376-7388

ER -