A water-soluble copper(II) complex for the selective fluorescence detection of nitric oxide/nitroxyl and imaging in living cells

Xiaolong Sun; Gyoungmi Kim; Yufang Xu; Juyoung Yoon; Tony D. James

doi:10.1002/cplu.201500436

A water-soluble copper(II) complex for the selective fluorescence detection of nitric oxide/nitroxyl and imaging in living cells

Xiaolong Sun, Gyoungmi Kim, Yufang Xu, Juyoung Yoon, Tony D. James

Research output: Contribution to journal › Article › peer-review

21 Citations (SciVal)

Abstract

A novel water-soluble copper(II) naphthalimide complex fluorescent probe was devised and displayed significant fluorescence turn-on response for nitric oxide and nitroxyl over other biologically relevant reactive oxygen species under physiological conditions. The dual-analyte recognition of this simple and sensitive probe was successfully applied for the imaging of exogenous and endogenous NO and HNO in living cells. Turn it on! A water-soluble copper(II) complex was prepared that displays impressive fluorescence response for nitric oxide and nitroxyl over other biologically relevant reactive species under physiological conditions. This sensor system was also used to image exogenous and endogenous NO and HNO in live cells (see figure).

Original language	English
Pages (from-to)	30-34
Number of pages	5
Journal	ChemPlusChem
Volume	81
Issue number	1
Early online date	16 Nov 2015
DOIs	https://doi.org/10.1002/cplu.201500436
Publication status	Published - Jan 2016

Keywords

cell imaging
copper
fluorescence probes
nitric oxide
nitroxyl

ASJC Scopus subject areas

Chemistry(all)

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10.1002/cplu.201500436

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AU - Xu, Yufang

AU - Yoon, Juyoung

AU - James, Tony D.

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AB - A novel water-soluble copper(II) naphthalimide complex fluorescent probe was devised and displayed significant fluorescence turn-on response for nitric oxide and nitroxyl over other biologically relevant reactive oxygen species under physiological conditions. The dual-analyte recognition of this simple and sensitive probe was successfully applied for the imaging of exogenous and endogenous NO and HNO in living cells. Turn it on! A water-soluble copper(II) complex was prepared that displays impressive fluorescence response for nitric oxide and nitroxyl over other biologically relevant reactive species under physiological conditions. This sensor system was also used to image exogenous and endogenous NO and HNO in live cells (see figure).

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KW - copper

KW - fluorescence probes

KW - nitric oxide

KW - nitroxyl

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A water-soluble copper(II) complex for the selective fluorescence detection of nitric oxide/nitroxyl and imaging in living cells

Abstract

Keywords

ASJC Scopus subject areas

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