TY - JOUR
T1 - A virtual look at Epstein-Barr virus infection: simulation mechanism
AU - Shapiro, M.
AU - Duca, K. A.
AU - Lee, K.
AU - Delgado-Eckert, E.
AU - Hawkins, J.
AU - Jarrah, A. S.
AU - Laubenbacher, R.
AU - Polys, N. F.
AU - Hadinoto, V.
AU - Thorley-Lawson, D. A.
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.
AB - Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.
UR - https://www.scopus.com/pages/publications/44449128825
U2 - 10.1016/j.jtbi.2008.01.032
DO - 10.1016/j.jtbi.2008.01.032
M3 - Article
SN - 0022-5193
VL - 252
SP - 633
EP - 648
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 4
ER -