A virtual look at Epstein-Barr virus infection: simulation mechanism

M. Shapiro, K. A. Duca, K. Lee, E. Delgado-Eckert, J. Hawkins, A. S. Jarrah, R. Laubenbacher, N. F. Polys, V. Hadinoto, D. A. Thorley-Lawson

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Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.
Original languageEnglish
Pages (from-to)633-648
JournalJournal of Theoretical Biology
Issue number4
Publication statusPublished - 1 Jun 2008

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Shapiro, M., Duca, K. A., Lee, K., Delgado-Eckert, E., Hawkins, J., Jarrah, A. S., Laubenbacher, R., Polys, N. F., Hadinoto, V., & Thorley-Lawson, D. A. (2008). A virtual look at Epstein-Barr virus infection: simulation mechanism. Journal of Theoretical Biology, 252(4), 633-648. https://doi.org/10.1016/j.jtbi.2008.01.032