Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.
Shapiro, M., Duca, K. A., Lee, K., Delgado-Eckert, E., Hawkins, J., Jarrah, A. S., Laubenbacher, R., Polys, N. F., Hadinoto, V., & Thorley-Lawson, D. A. (2008). A virtual look at Epstein-Barr virus infection: simulation mechanism. Journal of Theoretical Biology, 252(4), 633-648. https://doi.org/10.1016/j.jtbi.2008.01.032