A virtual look at Epstein-Barr virus infection: simulation mechanism

M. Shapiro; K. A. Duca; K. Lee; E. Delgado-Eckert; J. Hawkins; A. S. Jarrah; R. Laubenbacher; N. F. Polys; V. Hadinoto; D. A. Thorley-Lawson

doi:10.1016/j.jtbi.2008.01.032

A virtual look at Epstein-Barr virus infection: simulation mechanism

M. Shapiro, K. A. Duca, K. Lee, E. Delgado-Eckert, J. Hawkins, A. S. Jarrah, R. Laubenbacher, N. F. Polys, V. Hadinoto, D. A. Thorley-Lawson

Department of Life Sciences

Tufts University

Research output: Contribution to journal › Article › peer-review

28 Citations (SciVal)

Abstract

Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.

Original language	English
Pages (from-to)	633-648
Journal	Journal of Theoretical Biology
Volume	252
Issue number	4
DOIs	https://doi.org/10.1016/j.jtbi.2008.01.032
Publication status	Published - 1 Jun 2008

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10.1016/j.jtbi.2008.01.032

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abstract = "Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.",

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AU - Shapiro, M.

AU - Duca, K. A.

AU - Lee, K.

AU - Delgado-Eckert, E.

AU - Hawkins, J.

AU - Jarrah, A. S.

AU - Laubenbacher, R.

AU - Polys, N. F.

AU - Hadinoto, V.

AU - Thorley-Lawson, D. A.

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N2 - Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.

AB - Epstein-Barr virus (EBV) is an important human pathogen that establishes a life-long persistent infection and for which no precise animal model exists. In this paper, we describe in detail an agent-based model and computer simulation of EBV infection. Agents representing EBV and sets of B and T lymphocytes move and interact on a three-dimensional grid approximating Waldeyer's ring, together with abstract compartments for lymph and blood. The simulation allows us to explore the development and resolution of virtual infections in a manner not possible in actual human experiments. Specifically, we identify parameters capable of inducing clearance, persistent infection, or death.

U2 - 10.1016/j.jtbi.2008.01.032

DO - 10.1016/j.jtbi.2008.01.032

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VL - 252

SP - 633

EP - 648

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

IS - 4

ER -

A virtual look at Epstein-Barr virus infection: simulation mechanism

Abstract

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