A versatile lab to pilot scale continuous reaction system for supercritical fluid processing

Ulrich Hintermair, Christoph Roosen, Markus Kaever, Horst Kronenberg, Ralf Thelen, Stefan Aey, Walter Leitner, Lasse Greiner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A compact and versatile continuous reaction system for supercritical fluids as mobile phase was realised using commercially available components where possible. All process parameters of particular importance to the specific properties of near- or supercritical fluids such as pressure, temperature, and composition (p, T, x) can be accurately controlled over a wide flow range. The setup is completely automated by the help of computerised control and features a view cell for inline phase behavior observation. Coupling to supercritical fluid chromatography permits sampling under process conditions for reaction monitoring. Potential applications include continuous flow synthesis and catalysis, extractions, and other operations demanding controlled application of compressible gases. Highly efficient continuous flow asymmetric hydrogenation catalysis with integrated product separation is demonstrated.
Original languageEnglish
Pages (from-to)1275-1280
Number of pages6
JournalOrganic Process Research & Development
Volume15
Issue number6
Early online date18 Aug 2011
DOIs
Publication statusPublished - 18 Nov 2011

Fingerprint

Supercritical fluids
supercritical fluids
Catalysis
catalysis
Phase behavior
Processing
numerical control
Hydrogenation
Gases
chromatography
Sampling
hydrogenation
Monitoring
Chemical analysis
sampling
synthesis
products
cells
gases
Temperature

Cite this

A versatile lab to pilot scale continuous reaction system for supercritical fluid processing. / Hintermair, Ulrich; Roosen, Christoph; Kaever, Markus; Kronenberg, Horst; Thelen, Ralf; Aey, Stefan; Leitner, Walter; Greiner, Lasse.

In: Organic Process Research & Development, Vol. 15, No. 6, 18.11.2011, p. 1275-1280.

Research output: Contribution to journalArticle

Hintermair, U, Roosen, C, Kaever, M, Kronenberg, H, Thelen, R, Aey, S, Leitner, W & Greiner, L 2011, 'A versatile lab to pilot scale continuous reaction system for supercritical fluid processing', Organic Process Research & Development, vol. 15, no. 6, pp. 1275-1280. https://doi.org/10.1021/op200053w
Hintermair, Ulrich ; Roosen, Christoph ; Kaever, Markus ; Kronenberg, Horst ; Thelen, Ralf ; Aey, Stefan ; Leitner, Walter ; Greiner, Lasse. / A versatile lab to pilot scale continuous reaction system for supercritical fluid processing. In: Organic Process Research & Development. 2011 ; Vol. 15, No. 6. pp. 1275-1280.
@article{a78194ac4e3c4f4d81b66a7d8bceae49,
title = "A versatile lab to pilot scale continuous reaction system for supercritical fluid processing",
abstract = "A compact and versatile continuous reaction system for supercritical fluids as mobile phase was realised using commercially available components where possible. All process parameters of particular importance to the specific properties of near- or supercritical fluids such as pressure, temperature, and composition (p, T, x) can be accurately controlled over a wide flow range. The setup is completely automated by the help of computerised control and features a view cell for inline phase behavior observation. Coupling to supercritical fluid chromatography permits sampling under process conditions for reaction monitoring. Potential applications include continuous flow synthesis and catalysis, extractions, and other operations demanding controlled application of compressible gases. Highly efficient continuous flow asymmetric hydrogenation catalysis with integrated product separation is demonstrated.",
author = "Ulrich Hintermair and Christoph Roosen and Markus Kaever and Horst Kronenberg and Ralf Thelen and Stefan Aey and Walter Leitner and Lasse Greiner",
year = "2011",
month = "11",
day = "18",
doi = "10.1021/op200053w",
language = "English",
volume = "15",
pages = "1275--1280",
journal = "Organic Process Research and Development",
issn = "1083-6160",
publisher = "American Chemical Society",
number = "6",

}

TY - JOUR

T1 - A versatile lab to pilot scale continuous reaction system for supercritical fluid processing

AU - Hintermair, Ulrich

AU - Roosen, Christoph

AU - Kaever, Markus

AU - Kronenberg, Horst

AU - Thelen, Ralf

AU - Aey, Stefan

AU - Leitner, Walter

AU - Greiner, Lasse

PY - 2011/11/18

Y1 - 2011/11/18

N2 - A compact and versatile continuous reaction system for supercritical fluids as mobile phase was realised using commercially available components where possible. All process parameters of particular importance to the specific properties of near- or supercritical fluids such as pressure, temperature, and composition (p, T, x) can be accurately controlled over a wide flow range. The setup is completely automated by the help of computerised control and features a view cell for inline phase behavior observation. Coupling to supercritical fluid chromatography permits sampling under process conditions for reaction monitoring. Potential applications include continuous flow synthesis and catalysis, extractions, and other operations demanding controlled application of compressible gases. Highly efficient continuous flow asymmetric hydrogenation catalysis with integrated product separation is demonstrated.

AB - A compact and versatile continuous reaction system for supercritical fluids as mobile phase was realised using commercially available components where possible. All process parameters of particular importance to the specific properties of near- or supercritical fluids such as pressure, temperature, and composition (p, T, x) can be accurately controlled over a wide flow range. The setup is completely automated by the help of computerised control and features a view cell for inline phase behavior observation. Coupling to supercritical fluid chromatography permits sampling under process conditions for reaction monitoring. Potential applications include continuous flow synthesis and catalysis, extractions, and other operations demanding controlled application of compressible gases. Highly efficient continuous flow asymmetric hydrogenation catalysis with integrated product separation is demonstrated.

UR - http://www.scopus.com/inward/record.url?scp=81555201678&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1021/op200053w

U2 - 10.1021/op200053w

DO - 10.1021/op200053w

M3 - Article

VL - 15

SP - 1275

EP - 1280

JO - Organic Process Research and Development

JF - Organic Process Research and Development

SN - 1083-6160

IS - 6

ER -