A unification of mosaic structures in the human genome

M J Lercher, A O Urrutia, A Pavlicek, L D Hurst

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Abstract

The human genome is a mosaic structure on many levels: there exist cytogenetic bands, GC composition bands (isochores) and clusters of broadly expressed genes. How might these inter-relate? It has been proposed that to optimize gene regulation, housekeeping genes should concentrate on transcriptionally competent chromosomal domains. Prior evidence suggests that regions of high GC and R bands are associated with such domains. Here we report that broadly expressed genes cluster in regions of high GC, and in R and lightest Giemsa bands. This is not only a confirmation of the adaptive hypothesis, but is also the first direct systematic evidence of a general interdependence of expression patterns with base composition and chromosome structure.
Original languageEnglish
Pages (from-to)2411-2415
Number of pages5
JournalHuman Molecular Genetics
Volume12
Issue number19
DOIs
Publication statusPublished - 2003

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