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A stereochemically promiscuous 2-keto3-deoxygluconate aldolase has been used as an efficient biocatalyst to catalyse the aldol reaction of pyruvate with C-3- and C-4-aldoses to afford syn- and anti-3-deoxy-2-ulosonic acids in poor to good de. A continuous flow bioreactor containing immobilised aldolase has been developed that enables gram quantities of C-6- and C-7-3-deoxyhept-2-ulosonic acids to be produced in an efficient manner.
|Number of pages||5|
|Journal||Advanced Synthesis & Catalysis|
|Publication status||Published - 2007|
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- 1 Finished
METABOLIC PATHWAY PROMISCUITY: A STRUCTURAL, MECHANISTIC AN D BIOCATALYTIC INVESTIGATION
Hough, D. W.
Biotechnology and Biological Sciences Research Council
1/10/04 → 31/01/08
Project: Research council