A thermostable aldolase for the synthesis of 3-deoxy-2-ulosonic acids

H J Lamble, Sylvain F Royer, David W Hough, Michael J Danson, G L Taylor, S D Bull

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A stereochemically promiscuous 2-keto3-deoxygluconate aldolase has been used as an efficient biocatalyst to catalyse the aldol reaction of pyruvate with C-3- and C-4-aldoses to afford syn- and anti-3-deoxy-2-ulosonic acids in poor to good de. A continuous flow bioreactor containing immobilised aldolase has been developed that enables gram quantities of C-6- and C-7-3-deoxyhept-2-ulosonic acids to be produced in an efficient manner.
Original languageEnglish
Pages (from-to)817-821
Number of pages5
JournalAdvanced Synthesis & Catalysis
Volume349
Issue number6
DOIs
Publication statusPublished - 2007

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A thermostable aldolase for the synthesis of 3-deoxy-2-ulosonic acids. / Lamble, H J; Royer, Sylvain F; Hough, David W; Danson, Michael J; Taylor, G L; Bull, S D.

In: Advanced Synthesis & Catalysis, Vol. 349, No. 6, 2007, p. 817-821.

Research output: Contribution to journalArticle

Lamble, H J ; Royer, Sylvain F ; Hough, David W ; Danson, Michael J ; Taylor, G L ; Bull, S D. / A thermostable aldolase for the synthesis of 3-deoxy-2-ulosonic acids. In: Advanced Synthesis & Catalysis. 2007 ; Vol. 349, No. 6. pp. 817-821.
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