A thermostable aldolase for the synthesis of 3-deoxy-2-ulosonic acids

H J Lamble, Sylvain F Royer, David W Hough, Michael J Danson, G L Taylor, S D Bull

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17 Citations (SciVal)


A stereochemically promiscuous 2-keto3-deoxygluconate aldolase has been used as an efficient biocatalyst to catalyse the aldol reaction of pyruvate with C-3- and C-4-aldoses to afford syn- and anti-3-deoxy-2-ulosonic acids in poor to good de. A continuous flow bioreactor containing immobilised aldolase has been developed that enables gram quantities of C-6- and C-7-3-deoxyhept-2-ulosonic acids to be produced in an efficient manner.
Original languageEnglish
Pages (from-to)817-821
Number of pages5
JournalAdvanced Synthesis & Catalysis
Issue number6
Publication statusPublished - 2007

Bibliographical note

ID number: ISI:000246040000006


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