A theoretical description relating skin penetration to the thickness of the applied medicament

Richard H. Guy; Jonathan Hadgraft

doi:10.1016/0378-5173(80)90115-5

A theoretical description relating skin penetration to the thickness of the applied medicament

Research output: Contribution to journal › Article › peer-review

Abstract

Mathematical expressions have been derived which relate the degree of percutaneous penetration to the thickness of the applied base. The relative importance of simple physicochemical parameters is discussed and theoretical release curves provided to show the way in which optimum dosage regimens may be achieved.

Original language	English
Pages (from-to)	321-332
Number of pages	12
Journal	International Journal of Pharmaceutics
Volume	6
Issue number	3-4
DOIs	https://doi.org/10.1016/0378-5173(80)90115-5
Publication status	Published - 1980

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/0378-5173(80)90115-5

Cite this

@article{cc64b9407c80494b8f19a0b3375019b5,

title = "A theoretical description relating skin penetration to the thickness of the applied medicament",

abstract = "Mathematical expressions have been derived which relate the degree of percutaneous penetration to the thickness of the applied base. The relative importance of simple physicochemical parameters is discussed and theoretical release curves provided to show the way in which optimum dosage regimens may be achieved.",

author = "Guy, \{Richard H.\} and Jonathan Hadgraft",

year = "1980",

doi = "10.1016/0378-5173(80)90115-5",

language = "English",

volume = "6",

pages = "321--332",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier B.V.",

number = "3-4",

}

TY - JOUR

T1 - A theoretical description relating skin penetration to the thickness of the applied medicament

AU - Guy, Richard H.

AU - Hadgraft, Jonathan

PY - 1980

Y1 - 1980

N2 - Mathematical expressions have been derived which relate the degree of percutaneous penetration to the thickness of the applied base. The relative importance of simple physicochemical parameters is discussed and theoretical release curves provided to show the way in which optimum dosage regimens may be achieved.

AB - Mathematical expressions have been derived which relate the degree of percutaneous penetration to the thickness of the applied base. The relative importance of simple physicochemical parameters is discussed and theoretical release curves provided to show the way in which optimum dosage regimens may be achieved.

UR - https://www.scopus.com/pages/publications/0019275976

U2 - 10.1016/0378-5173(80)90115-5

DO - 10.1016/0378-5173(80)90115-5

M3 - Article

AN - SCOPUS:0019275976

SN - 0378-5173

VL - 6

SP - 321

EP - 332

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 3-4

ER -

A theoretical description relating skin penetration to the thickness of the applied medicament

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this